Evidence map›Paper›PMID 39509689›Full record

ArticleACS synthetic biology2024

Iron-Tannin Coating Reduces Clearance and Increases Tumor Colonization of Systemically Delivered Bacteria.

Sophia Windemuth, Jaeseung Hahn, Jicheng You, Zihan Wang, Suwan Ding, Stephanie Tarrab, Courtney Coker, Kam W Leong, Tal Danino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophia WindemuthDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.
Jaeseung HahnDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.
Jicheng YouDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.
Zihan WangDepartment of Chemical Engineering, Columbia University, New York, New York 10027, United States.
Suwan DingDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.ORCID 0000-0001-6259-9897
Stephanie TarrabDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.
Courtney CokerDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.
Tal DaninoDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, United States.ORCID 0000-0003-2713-7659

Funding

Programmable encapsulation systems to improve delivery of therapeutic bacteriaR01EB034302 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nicholas Arpaia, Tal Danino · 2023 to 2026
$2.5M
Programmable biohybrid system for cancer therapyK99CA283259 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAHN, JAESEUNG · 2024 to 2025
$344k
NCI NIH HHS K99 CA283259NIBIB NIH HHS R01 EB034302
6 · The paper itself

Abstract

Engineered bacteria offer a novel approach to targeted cancer therapy, but challenges remain in delivering enough bacteria safely for effective treatment. Previous efforts have used either a native or synthetic coating to achieve better control over the half-life of bacteria in the body but have limitations in delivery or versatility. In this work, we optimized and evaluated a synthetic coating for probiotic

Indexed as

Escherichia coliIronTanninsAnimalsCell Line, TumorFemaleHalf-LifeHumansMiceProbioticsIronTanninsbacterial therapycancerpolymer coatingsystemic delivery

Identifiers

PMID39509689
PMCPMC11949272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.