ArticleNeuropsychopharmacology reports2025
The association between benzodiazepine prescriptions and the risk of laxative use in schizophrenia treatment.
Article in Neuropsychopharmacology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prescribing Cascades: An Umbrella Review and Updated Systematic Review.Drugs & aging · 2026Pooled it
- The "GABAergic Brake" on the Spinal Defecation Reflex: A Proposed Neurobiological Model Explaining Clozapine- and Benzodiazepine-Induced Gastrointestinal Hypomotility and Ogilvie's Syndrome.Neuropsychopharmacology reports · 2026Article
- Optimizing Clozapine Monitoring in Older Adults: A Proposal for Ethnicity- and Sex-Informed Monitoring in Japanese Geriatric Patients.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- The association between benzodiazepine prescriptions and the risk of laxative use in schizophrenia treatment.Neuropsychopharmacology reports · 2025Article
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15 authors.
Funding
Abstract
aimConstipation is one of the most common adverse effects in schizophrenia treatment, and it can sometimes cause severe gastrointestinal disease. However, the results of association studies between constipation and psychotropic medications in patients with schizophrenia are inconsistent. Therefore, we investigated the characteristics of psychotropic and laxative prescriptions at discharge in patients with schizophrenia to clarify the association between psychotropics and constipation.
methodsWe analyzed the data of 139 patients with schizophrenia with or without laxative prescriptions at discharge from eight institutions in 2020.
resultsSixty-two patients were prescribed laxatives at discharge. The prescription of benzodiazepines in the laxative use group (66.1%) was significantly higher than that in the non-laxative use group (39.0%) (p = 1.4 × 10
conclusionBenzodiazepines may be associated with constipation in patients with schizophrenia. Therefore, clinicians should be cautious when prescribing benzodiazepines for the treatment of schizophrenia.
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