Evidence map›Paper›PMID 39509292›Full record

ArticleeLife2024

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells.

Yanling Huang, Haocong Mo, Jie Yang, Luyang Gao, Tian Tao, Qing Shu, Wenying Guo, Yawen Zhao, Jingya Lyu, Qimeng Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. L-cell-specificActa pharmaceutica Sinica. B · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway.Cellular and molecular life sciences : CMLS · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yanling Huang *Department of Physiology, School of Medicine, Jinan University, Guangzhou, China.
Haocong Mo *Department of Physiology, School of Medicine, Jinan University, Guangzhou, China.ORCID https://orcid.org/0009-0009-4778-8062
Jie Yang *Department of Pathology, School of Basic Medicine, Guangzhou Medical University, Guangdong, China.
Luyang Gao *Department of Physiology, School of Medicine, Jinan University, Guangzhou, China.ORCID https://orcid.org/0009-0005-6735-5353
Tian TaoDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, China.
Qing ShuDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, China.
Wenying GuoDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, China.
Yawen ZhaoDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, China.
Jingya LyuDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, China.
Qimeng WangBiotherapy Center, Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Jinghui GuoSchool of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Hening ZhaiEndoscopy Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Linyan ZhuDepartment of Pharmacology, School of Medicine, Jinan University, Guangzhou, China.
Hui ChenBiotherapy Center, Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-7218-9047
Geyang XuDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0002-5542-1350

Funding

Fundamental Research Funds for the Central Universities 21620423Guangdong Basic and Applied Basic Research Foundation 2024A1515010686Guangzhou Science and Technology Plan Project Funding 202201011353National Natural Science Foundation of China 81770794National Natural Science Foundation of China 82170818
6 · The paper itself

Abstract

Glucagon-like peptide 1 (GLP-1) is a gut-derived hormone secreted by intestinal L cells and vital for postprandial glycemic control. As open-type enteroendocrine cells, whether L cells can sense mechanical stimuli caused by chyme and thus regulate GLP-1 synthesis and secretion is unexplored. Molecular biology techniques revealed the expression of Piezo1 in intestinal L cells. Its level varied in different energy status and correlates with blood glucose and GLP-1 levels. Mice with L cell-specific loss of Piezo1 (

Indexed as

Glucagon-Like Peptide 1Ion ChannelsAnimalsDiet, High-FatGlucose IntoleranceL CellsMaleMechanistic Target of Rapamycin Complex 1Mechanotransduction, CellularMiceMice, Inbred C57BLMice, KnockoutSignal TransductionGlucagon-Like Peptide 1Ion ChannelsMechanistic Target of Rapamycin Complex 1Piezo1 protein, mouseCaMKIVCaMKKβglucagon-like peptide 1intestinal L cellsmechanistic target of rapamycinmedicinemousePiezo1

Identifiers

PMID39509292
PMCPMC11542922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.