Evidence map›Paper›PMID 39509189›Full record

ArticleBehavioral neuroscience2025

Methylphenidate differentially affects the social ultrasonic vocalizations of wild-type and prodromal Parkinsonian rats.

Sarah A Lechner, Cynthia A Kelm-Nelson, Michelle R Ciucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah A LechnerDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison.ORCID 0009-0000-5328-1254
Cynthia A Kelm-NelsonDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison.
Michelle R CiucciDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison.

Funding

Preclinical trial for dysarthria treatment in Parkinson diseaseR01DC018584 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CIUCCI, MICHELLE RENEE · 2021 to 2025
$3.3M
Pathways, mechanisms, and treatments of vocal communication deficits in a Parkinson rat modelR01NS117469 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Cynthia A Kelm-Nelson · 2020 to 2026
$3.0M
NIDCD NIH HHS R01 DC018584NIH HHSNINDS NIH HHS R01 NS117469
6 · The paper itself

Abstract

Prodromal signs of Parkinson's disease (PD), including vocal communication deficits, are poorly understood and do not respond adequately to current pharmacologic treatments. Norepinephrine dysfunction is involved early in PD; thus, drug therapies targeting norepinephrine may be useful as a treatment of prodromal signs. This study used a validated, translational rodent model of prodromal PD, the male

Indexed as

Central Nervous System StimulantsMethylphenidateParkinson DiseaseVocalization, AnimalAnimalsAnxietyDisease Models, AnimalDose-Response Relationship, DrugMaleMotor ActivityParkinsonian DisordersProdromal SymptomsProtein KinasesPTEN-Induced Putative KinaseRatsRats, Sprague-DawleyCentral Nervous System StimulantsMethylphenidateProtein KinasesPTEN-Induced Putative Kinase

Identifiers

PMID39509189
PMCPMC11747832

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.