Evidence map›Paper›PMID 39509060›Full record

ArticleCancer immunology, immunotherapy : CII2024

Spontaneous high clonal expansion of Wilms' tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms' tumor gene 1-expressing solid tumor.

Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa and 11 more

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Soyoko MorimotoDepartment of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Osaka, Japan. soyoko@sahs.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-4939-0455
Yukie TanakaDepartment of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.
Jun NakataDepartment of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Fumihiro FujikiDepartment of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.
Kana HasegawaLaboratory of Cellular Immunotherapy, World Premier International Research Center Initiative Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan.
Hiroko NakajimaDepartment of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Sumiyuki NishidaStrategic Global Partnership & X (Cross)-Innovation Initiative Graduate School of Medicine, Osaka University and Osaka University Hospital, Osaka, Japan.
Akihiro TsuboiDepartment of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.
Naoki HosenLaboratory of Cellular Immunotherapy, World Premier International Research Center Initiative Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan.
Naoki KagawaDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Motohiko MarunoDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Akira MyouiMedical Center for Translational Research, Department of Medical Innovation, Osaka University Hospital, Osaka, Japan.
Takayuki EnomotoDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Shuichi IzumotoDepartment of Neurosurgery, Hyogo College of Medicine, Hyogo, Japan.
Mitsugu SekimotoDepartment of Gastroenterological Surgery Graduate School of Medicine, Osaka University, Osaka, Japan.
Naoya HashimotoDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Toshiki YoshimineDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Yusuke OjiDepartment of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Yoshihiro OkaDepartment of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Osaka, Japan.
Haruo SugiyamaDepartment of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.

Funding

Japan Society for the Promotion of Science JP15K18446, JP17K07216, JP23K06761Japan Society for the Promotion of Science JP19K07729, JP22K07251Japan Society for the Promotion of Science JP26430162
6 · The paper itself

Abstract

Wilms' tumor protein 1 (WT1)-targeted immunotherapy has been used in patients with leukemia and solid tumors. However, the spontaneous WT1-specific immune response before WT1 peptide vaccination in patients with WT1-expressing tumors (PTs) remains unclear. Therefore, we investigated whether WT1-specific cytotoxic CD8

Indexed as

T-Lymphocytes, CytotoxicWT1 ProteinsAdultAgedFemaleHLA-A2 AntigenHumansMaleMiddle AgedNeoplasmsWilms TumorHLA-A2 AntigenWT1 protein, humanWT1 ProteinsClonalitySingle-cellTCR repertoireWT1WT1126-CTLs

Identifiers

PMID39509060
PMCPMC11543974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.