Evidence map›Paper›PMID 39508922›Full record

ArticleMolecular biology reports2024

Potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene polymorphism in Egyptian type 2 diabetic patients: a single-center study.

Abdallah S Abdelazem, Osama Abdelaziz Gaber, Samia Hussein, Fatma Mahmoud Elsaid Nasr, Eman A M Elshorbagy, Sara Mohammed Ibrahim, Abdullah Mohammad Abdel-Hameed, Mai Hamdy Rashad, Amal S El-Shal, Al-Shabrawy M Abdelnabi

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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10 authors.

Abdallah S AbdelazemDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez University, P.O. Box: 43221, Suez, Egypt.
Osama Abdelaziz GaberMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Samia HusseinMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. samiahussein82@hotmail.com.
Fatma Mahmoud Elsaid NasrDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez University, P.O. Box: 43221, Suez, Egypt.
Eman A M ElshorbagyInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sara Mohammed IbrahimClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abdullah Mohammad Abdel-HameedClinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Mai Hamdy RashadDepartment of Microbiology, Faculty of Medicine, Suez University, P.O. Box: 43221, Suez, Egypt.
Amal S El-ShalMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Al-Shabrawy M AbdelnabiInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe KCNJ11 gene belongs to the potassium channel gene family. It has a major role in the secretion of insulin. Genetic variations in KCNJ11 are possibly responsible for the progression of type 2 diabetes mellitus (T2DM). In this study, we investigated the possible correlation between KCNJ11 (rs5210) gene polymorphism and T2DM. SUBJECTS AND

methodThis study included 92 individuals divided into two groups. Group 1 included 46 type 2 diabetic patients. Group 2 (control group) included 46 healthy participants. A complete history was taken and a full physical examination was performed. Anthropometric data were measured. Laboratory investigations included fasting blood glucose (FBG), two hours post-prandial blood glucose (2HPPBG), glycated hemoglobin (HbA1c), and fasting lipid profile. KCNJ11 (rs5210) single nucleotide polymorphism was detected by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP).

resultsBoth AG and GG genotypes were associated with increased risk for T2DM (OR 5.2, 95% CI 1.32-20.5, P = 0.01 for AG; and OR 18.2, 95% CI 2.99-31.7, P = 0.002 for GG). Also, the frequency of the G allele was significantly higher in type 2 diabetic patients compared to healthy controls (50% versus 23.9%, respectively). The G allele of rs5210 in KCNJ11 contributed to an increased risk of T2DM (OR 3.18, 95% CI 1.31-7.75, P = 0.01). There was a statistically significant association between increased 2HPPBG and HbA1c levels and the carrier of AG and GG genotypes (P = 0.01 and 0.007, respectively). There was a statistically significant association between total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and high-density lipoprotein-cholesterol (HDL-c) levels and the carrier of AG and GG genotypes (P < 0.001, 0.02, and 0.007, respectively). Regression analysis detected that body mass index (BMI), 2HPPBG, TC, triglycerides (TG), and the G allele of rs5210 in KCNJ11 gene showed a significant association with T2DM (P = 0.004, 0.042, 0.003, 0.006, and 0.01, respectively) while no association was observed with FBG, HbA1c, LDL-c or HDL-c (P = 0.099, 0.123, 0.522, and 0.765, respectively).

conclusionKCNJ11 rs5210 genetic polymorphism may raise the risk for the occurrence of T2DM among Egyptians.

Indexed as

Diabetes Mellitus, Type 2Genetic Predisposition to DiseasePolymorphism, Single NucleotidePotassium Channels, Inwardly RectifyingAdultAllelesBlood GlucoseCase-Control StudiesEgyptFemaleGene FrequencyGenotypeGlycated HemoglobinHumansKcnj11 ChannelMaleBlood GlucoseGlycated HemoglobinKcnj11 ChannelPotassium Channels, Inwardly RectifyingDiabetes mellitusGenetic polymorphismLipid profile

Identifiers

PMID39508922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.