Evidence map›Paper›PMID 39508889›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Association of daily physical activity with pulmonary artery pressure in HFpEF and HFmrEF NYHA class III patients: a pilot trial-feasibility and first results.

Ester J Herrmann, Denise Lange, Jennifer Hannig, Gina Zimmer, Dimitri Gruen, Till Keller, Albin Edegran, Linda S Johnson, Samuel Sossalla, Michael Guckert and 1 more

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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ester J HerrmannDepartment of Medicine I, Cardiology and Angiology, University Hospital Giessen and Marburg, Justus Liebig University, Klinikstr. 33, 35392, Giessen, Germany.
Denise LangeInstitute of Mathematics, Natural Sciences and Data Processing, Technische Hochschule Mittelhessen, University of Applied Sciences, 61169, Friedberg, Germany.
Jennifer HannigCognitive Information Systems Group, Kompetenzzentrum Für Informationstechnologie (KITE), Technische Hochschule Mittelhessen, University of Applied Sciences, 61169, Friedberg, Germany.
Gina ZimmerDepartment of Medicine I, Cardiology and Angiology, University Hospital Giessen and Marburg, Justus Liebig University, Klinikstr. 33, 35392, Giessen, Germany.
Dimitri GruenJustus-Liebig-University, 35392, Giessen, Germany.
Till KellerJustus-Liebig-University, 35392, Giessen, Germany.
Albin EdegranMEDICALgorithmics, Warsaw, Poland.
Linda S JohnsonDepartment of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
Samuel SossallaDepartment of Medicine I, Cardiology and Angiology, University Hospital Giessen and Marburg, Justus Liebig University, Klinikstr. 33, 35392, Giessen, Germany.
Michael GuckertInstitute of Mathematics, Natural Sciences and Data Processing, Technische Hochschule Mittelhessen, University of Applied Sciences, 61169, Friedberg, Germany.
Birgit AssmusDepartment of Medicine I, Cardiology and Angiology, University Hospital Giessen and Marburg, Justus Liebig University, Klinikstr. 33, 35392, Giessen, Germany. birgit.assmus@innere.med.uni-giessen.de.ORCID http://orcid.org/0000-0003-2658-6444

Funding

Deutsche Forschungsgemeinschaft Project B09Deutsche Forschungsgemeinschaft SFB 1213
6 · The paper itself

Abstract

introductionSupervised physical exercise has been shown to benefit patients with heart failure with preserved/mildly reduced ejection fraction (HFpEF/HfmrEF) by improving symptoms and diastolic function. This study aimed to investigate the correlation between unsupervised daily physical activity and changes in daily pulmonary artery pressure (PAP) in patients with stable NYHA class III heart failure (HF) and left ventricular ejection fraction (LVEF) of 45% or higher.

methodsDaily physical activity was monitored over a 3-month period using a Holter-ECG with an accelerometer that calculated an activity-associated, heart rate-derived metabolic equivalent of task (MET) score. PAP was measured using an implanted sensor in 17 patients.

resultsDuring 3 months of PAP monitoring in parallel with Holter ECG in our HF patients (median age 77 [IQR 72-79.5] years, LVEF 55 [49-56] %, mean cardiac index 1.9 ± 0.3), mean, diastolic, and systolic PAP remained unchanged. Patients engaged in unsupervised daily activity with a mean MET score of 5.0 ± 1.2 and a median daily duration of 41 [13-123] minutes. Intensity of daily activity was associated with a higher diastolic PAP on the following day (R

conclusionsTracking changes in daily PAP based on intensity and duration of unsupervised daily activity using implanted sensors and a PocketECG

Indexed as

ExerciseHeart FailurePulmonary ArteryPulmonary Wedge PressureStroke VolumeVentricular Function, LeftAgedElectrocardiography, AmbulatoryFeasibility StudiesFemaleHumansMalePilot ProjectsDaily activityHeart failure with preserved ejection fractionMET scorePulmonary artery pressure

Identifiers

PMID39508889
PMCPMC12894114

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.