Evidence map›Paper›PMID 39508598›Full record

ArticleMovement disorders clinical practice2025

Differentiating Postural and Kinetic Tremor Responses to Deep Brain Stimulation in Essential Tremor.

Rebecca D Butler, Annemarie K Brinda, Madeline Blumenfeld, Marina N Bryants, Peter M Grund, Shivansh R Pandey, Chelsea K S Cornish, Disa Sullivan, Jordan Krieg, Matthew Umoh and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rebecca D ButlerDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-2529-5971
Annemarie K BrindaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Madeline BlumenfeldDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Marina N BryantsDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Peter M GrundDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Shivansh R PandeyDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Chelsea K S CornishDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Disa SullivanDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Jordan KriegDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Matthew UmohDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Leonardo AlmeidaDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Tseganesh OrcuttDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Scott E CooperDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Matthew D JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0001-9686-5540

Funding

Algorithms for programming deep brain stimulation systemsR01NS081118 · NINDS · UNIVERSITY OF MINNESOTA · PI HAREL, NOAM, JOHNSON, MATTHEW DOUGLAS · 2012 to 2023
$4.0M
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDiseaseR01NS124814 · NINDS · UNIVERSITY OF MINNESOTA · PI SCOTT E COOPER · 2022 to 2026
$3.7M
Progression and differential control of postural and kinetic tremor with deep brain stimulationF31NS129241 · NINDS · UNIVERSITY OF MINNESOTA · PI BUTLER, REBECCA DORAN · 2022 to 2024
$71k
NINDS NIH HHS F31 NS129241NINDS NIH HHS F31-NS129241NINDS NIH HHS R01 NS081118NINDS NIH HHS R01-NS081118NINDS NIH HHS R01 NS124814
6 · The paper itself

Abstract

backgroundWhile deep brain stimulation (DBS) targeting the ventral intermediate nucleus (VIM) of thalamus or posterior subthalamic area (PSA) can suppress forms of action tremor in people with Essential Tremor, previous studies have suggested postural tremor may respond more robustly than kinetic tremor to DBS.

objectivesIn this study, we aimed to more precisely quantify the (1) onset/offset dynamics and (2) steady-state effects of VIM/PSA-DBS on postural and kinetic tremor.

methodsTremor data from wireless inertial measurement units were collected from 11 participants with ET (20 unilaterally assessed DBS leads). Three postural hold tasks and one kinetic task were performed with stimulation turned off, in 2-min intervals after enabling unilateral DBS at the clinician-optimized DBS setting (15 min), and in 2-min intervals following cessation of DBS (5 min).

resultsAt baseline, kinetic tremor had significantly higher amplitudes, standard deviation, and frequency than postural tremor (P < 0.001). DBS had a more robust acute effect on postural tremors (54% decrease, P < 0.001), with near immediate tremor suppression in amplitude and standard deviation, but had non-significant improvement of kinetic tremor on the population-level across the wash-in period (34% decrease). Tremor response was not equivalent between wash-in and wash-out timepoints and involved substantial individual variability including task-specific rebound or long wash-out effects.

conclusionsProgramming strategies for VIM/PSA-DBS should consider the individual temporal and effect size variability in postural versus kinetic tremor improvement. Improved targeting and programming strategies around VIM and PSA may be necessary to equivalently suppress both postural and kinetic tremors.

Indexed as

Deep Brain StimulationEssential TremorPostureTremorAgedFemaleHumansMaleMiddle AgedVentral Thalamic Nucleideep brain stimulationessential tremorkinetic tremorpostural tremor

Identifiers

PMID39508598
PMCPMC11802662

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.