Evidence map›Paper›PMID 39507968›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2024

[miR-2110 Affects the Biological Behaviors of Lung Adenocarcinoma by Regulating CDT1].

Yuan Mi, Xuzhe Li, Cong Wang, Chenxi Lin, Zhichao Zhao, Xiaofei Yan, Ping Shi, Lei Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuan Mi（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Xuzhe Li（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Cong Wang（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Chenxi Lin（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Zhichao Zhao（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Xiaofei Yan（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Ping Shi（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.
Lei Wang（ 050017） Department of Emergency, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effect of miR-2110 on the biological behaviors, such as cell proliferation, apoptosis, and metastasis, of lung adenocarcinoma (LUAD) cells by means of cell and animal experiments. Methods: Bioinformatics websites, including ENCORI, TargetScan, miRTarBase, and Tarbase, were used to analyze the changes in the expression of miR-2110 in LUAD samples and to predict miR-2110 target. LUAD tissue samples and cells were collected and the changes in the expression of miR-2110 were verified through PCR technology. CCK-8 assay, clonogenic assay, Transwell assay, and flow cytometry were conducted to analyze alterations in the functions of LUAD cells. In addition, 10 BALB/c female nude mice aged 6 to 8 weeks were randomly divided into 2 groups, and the effect of miR-2110 on LUAD was investigated by Results: miR-2110 was significantly decreased in LUAD tissues and cells compared with the normal lung tissues. miR-2110 overexpression inhibited the proliferation and metastasis of LUAD cells and promoted the apoptosis of tumor cells ( Conclusion: miR-2110 can inhibit proliferation and metastasis of LUAD by targeting CDT1, providing a new rationale for the treatment of LUAD.

Indexed as

Adenocarcinoma of LungApoptosisCell Cycle ProteinsCell ProliferationLung NeoplasmsMicroRNAsAnimalsCell Line, TumorCell MovementFemaleGene Expression Regulation, NeoplasticHumansMiceMice, Inbred BALB CMice, NudeNeoplasm MetastasisCDT1 protein, humanCell Cycle ProteinsMicroRNAsMIRN2110 microRNA, humanAdenocarcinoma of lungCDT1miR-2110Tumor proliferation

Identifiers

PMID39507968
PMCPMC11536258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.