ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2024
[Utilizing Sonodynamic Therapy-Induced Pyroptosis for Liver Cancer Therapy].
Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver cancer is one of the leading causes of cancer-related deaths worldwide. However, all liver cancer treatment options currently available fail to achieve a complete cure. Recently, research on pyroptosis has attracted significant attention from researchers in the field of cancer therapy. Pyroptosis is an inflammatory cell death closely related to oxidative stress caused by reactive oxygen species (ROS). The induction of pyroptosis can lead to the inhibition of tumor proliferation and the improvement of tumor immune responsiveness and is considered a novel therapeutic mechanism that can be utilized to develop new cancer therapies. Sonodynamic therapy (SDT), which involves a synergistic application of sonosensitizers and low-intensity focused ultrasound to generate cytotoxic ROS, demonstrates certain advantages and potentials in the treatment of liver cancer. However, liver cancer treatment utilizing SDT is still in the stage of preclinical research, and the specific conditions of ultrasound treatment, the biological effects, and the mechanisms of action are not fully understood. In this review, we discussed the potential of utilizing pyroptosis in liver cancer treatment, the mechanism of cancer therapy with ROS generated by SDT, and the latest findings concerning SDT from clinical and basic research. We discussed the utilization of SDT to force the accumulation of ROS in tumors to exceed the cytotoxicity threshold. Thus, SDT promotes pyroptosis and enhances the immune response to cancer. Furthermore, we discussed the prospects for applying the mechanism of SDT-induced pyroptosis in cancer therapy, thereby providing a better theoretical and experimental foundation for the clinical translation of SDT for liver cancer treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.