ArticleFrontiers in nutrition2024
Vitamin C intake and osteoarthritis: findings of NHANES 2003-2018 and Mendelian randomization study.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association of the combined atherosclerosis index of plasma and frailty index with arthritis in middle-aged and older adults: a cohort study.Scientific reports · 2026Article
- Revealing the Diagnostic Potential of Three RHO GTPase-Related Genes in Osteoarthritis Based on Single-Cell RNA Sequencing and GEO Dataset Analysis.International journal of genomics · 2026Article
- Association of inflammation geriatric nutritional risk index with all-cause and CVD mortality in patients with osteoarthritis.Frontiers in nutrition · 2025Article
- Drug Delivery Systems Targeting the Knee Microenvironment: A Prospective Strategy for Knee Osteoarthritis Treatment.Drug design, development and therapy · 2025Review
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Authors and funding
7 authors.
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Abstract
Background: The role of vitamin C in osteoarthritis (OA) is still a subject of debate. Our aim was to combine the National Health and Nutrition Examination Survey (NHANES) and MR studies to explore the relationship between vitamin C intake and OA. Methods: Clinical information on participants during NHANES 2003-2018 was collected and the relationship between vitamin C intake and OA risk was assessed using logistic regression modelling. In MR analyses, three methods were used to explore the causality of vitamin C intake with OA. Sensitivity analysis to verify the stability of the MR study. Results: The cross-sectional study included a total of 31,527 participants, categorizing them into low (<30.2 mg), medium (30.2-93.0 mg) and high (>93.0 mg) level groups based on their vitamin C intake levels. Logistic regression models showed that vitamin C intake was not associated with OA risk ( Conclusion: Our cross-sectional and MR studies showed that vitamin C intake was not associated with OA risk. More researches are needed in the future to investigate the link between vitamin C and OA.
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