Evidence map›Paper›PMID 39507369›Full record

ArticleAdvanced synthesis & catalysis2023

Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity.

Matthew S Lish, Jillian E Milanes, Kyana M Sanders, Ilia A Guzei, James C Morris, Jennifer E Golden

Abstract read
In one paragraph

Article in Advanced synthesis & catalysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew S LishDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.
Jillian E MilanesEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, 29634, United States.
Kyana M SandersDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.
Ilia A GuzeiMolecular Structure Laboratory, Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
James C MorrisEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, 29634, United States.
Jennifer E GoldenDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, United States.

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI KERRY Scot SMITH · 2022 to 2026
$13.5M
Accelerated discovery of cell-active SARS-CoV-2 polymerase inhibitors via molecular dynamic guided screening and optimizationR21AI161232 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDEN, JENNIFER E. · 2021 to 2021
$443k
Approaches for genetic manipulation of Naegleria fowleriR21AI175463 · NIAID · CLEMSON UNIVERSITY · PI MORRIS, JAMES CULVIN · 2023 to 2024
$419k
NIAID NIH HHS R21 AI161232NIAID NIH HHS R21 AI175463NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

A three-step synthesis of anti-amoebic, ring-fused mackinazolinones has been developed. A Mannich-type reaction between quinazolin-4-ones and

Indexed as

AmidineMannichNaegleria fowleriQuinazolinoneRearrangement

Identifiers

PMID39507369
PMCPMC11537234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.