Evidence map›Paper›PMID 39507365›Full record

ArticleLancet regional health. Americas2024

Clinical and functional assessment of SARS-CoV-2 sequelae among young marines - a panel study.

Chad K Porter, Charmagne G Beckett, Elizabeth Cooper, Lindsey White, David Wallace, Silvia Jakubski, David Boulifard, Megan Schilling, Peifang Sun, Jan Marayag and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet regional health. Americas, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chad K PorterNaval Medical Research Command, Silver Spring, MD, USA.
Charmagne G BeckettNaval Medical Research Command, Silver Spring, MD, USA.
Elizabeth CooperNaval Medical Research Command, Silver Spring, MD, USA.
Lindsey WhiteNaval Medical Research Command, Silver Spring, MD, USA.
David WallaceNaval Medical Research Command, Silver Spring, MD, USA.
Silvia JakubskiNaval Medical Research Command, Silver Spring, MD, USA.
David BoulifardNaval Medical Research Command, Silver Spring, MD, USA.
Megan SchillingNaval Medical Research Command, Silver Spring, MD, USA.
Peifang SunNaval Medical Research Command, Silver Spring, MD, USA.
Jan MarayagNaval Medical Research Command, Silver Spring, MD, USA.
Amethyst MarroneNaval Medical Research Command, Silver Spring, MD, USA.
Edgar O Nunez-HernandezNaval Medical Research Command, Silver Spring, MD, USA.
Sindhu VangetiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Clare MillerDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yongchao GeDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Irene RamosDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carl GoforthNaval Medical Research Command, Silver Spring, MD, USA.
Stuart C SealfonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew G LetiziaNaval Medical Research Command, Silver Spring, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Long-term SARS-CoV-2 adverse health outcomes are of significant concern, especially among young adults with the potential for the greatest long-term morbidity. We sought to assess and characterize these outcomes in a cohort of Marines. Methods: We used a cohort of US Marines from a previous longitudinal, prospective observational study of acute SARS-CoV-2, most of whom were enrolled prior to infection. A panel study was established to assess for post-acute sequelae of COVID-19 (PASC), defined as symptoms at least 4 weeks after symptom onset or diagnosis. Symptoms were assessed through questionnaires and validated quality of health metrics. Periodic US Marine Corps fitness testing metrics provided an additional standardized functional assessment and were compared to a pre-pandemic cohort. Findings: Globally dispersed Marine participants (n = 899) seen an average of 330 days following initial enrollment were predominately male (n = 825, 91.7%), White (n = 613, 71.6%) or Black (n = 149, 17.4%) with a median age of 18 years (interquartile range: 18-19). Among 798 SARS-CoV-2 infected participants, 197 (24.7%) developed PASC. The most prevalent symptoms were loss of taste and/or smell (n = 82; 41.6%), shortness of breath (n = 74; 37.6%), and cough (n = 45; 22.8%). Those with PASC had higher rates and severity of somatic (p < 0.0001), general depressive (p < 0.0001), and anxiety (p = 0.005) symptoms. Compared to a historic cohort of Marines, participants with PASC scored worse on their physical fitness assessments due to slower run times (p = 0.002). Those with PASC continued to have decreased physical performance one year after completing initial training. Interpretation: In this population of healthy young adult US Marines with mostly either asymptomatic or mild acute COVID-19, one fourth reported physical, cognitive, or psychiatric long-term sequelae of infection. The Marines affected with PASC showed evidence of long-term decrease in functional performance suggesting that SARS-CoV-2 infection may negatively affect health for a significant proportion of young adults. Funding: Defense Health Agency and Defense Advanced Research Projects Agency.

Indexed as

COVID-19Long COVIDPASCPost-acute sequelae of COVID-19SARS-CoV-2

Identifiers

PMID39507365
PMCPMC11539644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.