Evidence map›Paper›PMID 39507274›Full record

ArticleBrain communications2024

White matter protection with insulin-like growth factor-1 after hypoxia-ischaemia in preterm foetal sheep.

Guido Wassink, Kenta H T Cho, Sam Mathai, Christopher A Lear, Justin M Dean, Alistair J Gunn, Laura Bennet

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guido WassinkDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
Kenta H T ChoDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
Sam MathaiDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
Christopher A LearDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.ORCID https://orcid.org/0000-0002-8937-0846
Justin M DeanDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.ORCID https://orcid.org/0000-0002-1377-0878
Alistair J GunnDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.ORCID https://orcid.org/0000-0003-0656-7035
Laura BennetDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal hypoxia-ischaemia in extremely preterm infants is associated with long-term neurodevelopmental impairment, for which there is no specific treatment. Insulin-like growth factor-1 can reduce acute brain injury, but its effects on chronic white matter injury after hypoxia-ischaemia are unclear. Preterm-equivalent foetal sheep (0.6 gestation) received either sham-asphyxia or asphyxia induced by umbilical cord occlusion for 30 min, and recovered for either 3 or 35 days after asphyxia. The 35 day recovery groups received either an intracerebroventricular infusion of insulin-like growth factor-1 (1 µg/24 h) or vehicle, from 3 to 14 days after asphyxia. Asphyxia was associated with ventricular enlargement, and loss of frontal and parietal white matter area (

Indexed as

hypoxia-ischaemiainsulin-like growth factor-1neonateprematuritywhite matter injury

Identifiers

PMID39507274
PMCPMC11539755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.