Evidence map›Paper›PMID 39507250›Full record

ArticleiScience2024

Delineating sex-specific circulating host response signatures associated with COVID-19 severity and mortality.

Nick Keur, Antine W Flikweert, Isis Ricaño-Ponce, Anneke C Muller Kobold, Simone van der Sar-van der Brugge, Izabela A Rodenhuis-Zybert, Kieu T T Le, Matijs van Meurs, Marco J Grootenboers, Peter H J van der Voort and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nick KeurDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud UMC, Nijmegen, the Netherlands.
Antine W FlikweertDepartment of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands.
Isis Ricaño-PonceDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud UMC, Nijmegen, the Netherlands.
Anneke C Muller KoboldDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Simone van der Sar-van der BruggeDepartment of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands.
Izabela A Rodenhuis-ZybertDepartment of Medical Microbiology & Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Kieu T T LeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Matijs van MeursDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marco J GrootenboersDepartment of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands.
Peter H J van der VoortDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Peter HeeringaDepartment of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Vinod KumarDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud UMC, Nijmegen, the Netherlands.
Jill MoserDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male SARS-CoV-2-infected patients have higher hospitalization rates, ICU admissions, and mortality compared to females, yet with unclear underlying mechanisms. We investigated the influence of biological sex on COVID-19 severity and patient outcomes. We profiled 41 circulating host response markers and identified differentially regulated proteins based on disease severity using covariates, such as sex, age, BMI, diabetes, and corticosteroid administration. IL-8, D-dimer, S100B, IL-6, Angpt-2, MMP-8, TNF-R1, u-PAR, u-PA, osteopontin, IL-13, TNF-α, pentraxin-3, P-selectin, fractalkine, and SP-D levels were elevated in critically ill COVID-19 males compared to severe cases. In contrast, IL-8, D-dimer, IL-6, Angpt-2, Tie-2, uPAR, and SP-D were higher in females with critical-COVID-19 than in severe cases. Notably, D-dimer, IL-6, pentraxin-3, and S100B were associated with male mortality, yet none of the measured plasma proteins associated with female mortality. Our study delineated distinct sex-specific plasma protein signatures linked to the severity and mortality of COVID-19 patients.

Indexed as

MicrobiologyMolecular biologyVirology

Identifiers

PMID39507250
PMCPMC11539596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.