ArticleTranslational lung cancer research2024
Insights into sex differences in perioperative outcomes of non-small cell lung cancer patients.
Article in Translational lung cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Sex- and Diabetes-Dependent Perioperative Model for End-Stage Liver Disease Trajectories Identify Distinct Hepatorenal Stress Phenotypes After Surgical Coronary Revascularization.Journal of clinical medicine · 2026Article
- Systematic Pathway Screening via Integrated Machine Learning Identifies FOXO-Mediated Transcription Signature for Robust Immunotherapy Response Prediction in Non-Small Cell Lung Cancer.Human mutation · 2026Article
- Sex-based survival disparities in patients with stage I-III non-small cell lung cancer vary by treatment modality.Frontiers in oncology · 2026Article
- Should Muscle Mass be Incorporated into Surgical Decision-Making for Early-Stage Lung Cancer?Annals of surgical oncology · 2025Article
- Aging population of tracheal, bronchus, and lung cancer: global, regional, and national burden-insights from the Global Burden of Disease Study 2021.Journal of thoracic disease · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: The appreciation of sex differences is substantial for precise cancer management. Surgery is the main treatment for non-small cell lung cancer (NSCLC). We aimed to identify sex differences on perioperative outcomes in NSCLC patients and to uncover the origins of sex effect in outcomes using a Chinese cohort. Methods: We retrospectively enrolled patients undergoing NSCLC surgery in the Western China Lung Cancer Database from January 2014 to April 2021. We compared baseline characteristics and perioperative outcomes between male and female. Multivariable analyses were performed. We conducted causal mediation analysis to identify drivers to sex differences in perioperative outcomes. Results: Altogether, data of 10,181 patients (5,738 women and 4,443 men) were analyzed. Women had lower incidence of complications (5.05% Conclusions: Female NSCLC patients demonstrated lower incidence of complications, shorter postoperative length of stays, and less hospitalization cost after surgery. Those differences between men and women could be explained by their inherent biological differences and baseline health status. Perioperative management strategies for NSCLC should prioritize recognizing the potentially poorer outcomes among male patients and implementing tailored precautions accordingly.
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