Evidence map›Paper›PMID 39506961›Full record

ArticleHeliyon2024

Brain-targeting liposome-based

Ni Wang, Tammee M Parsons, Yingxue Ren, Yining Pan, Aishe Kurti, Skylar C Starling, Chinenye Muolokwu, Jagdish Singh, Takahisa Kanekiyo

Abstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ni WangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Tammee M ParsonsDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Yingxue RenDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Yining PanDepartment of Health Outcomes & Biomedical Informatics, University of Florida College of Medicine, Gainesville, FL, 32611, USA.
Aishe KurtiDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Skylar C StarlingDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Chinenye MuolokwuDepartment of Pharmaceutical Sciences School of Pharmacy, North Dakota State University, Fargo, ND, 58108, USA.
Jagdish SinghDepartment of Pharmaceutical Sciences School of Pharmacy, North Dakota State University, Fargo, ND, 58108, USA.
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.

Funding

Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Takahisa Kanekiyo · 2021 to 2026
$42.0M
Impact of ApoE2 on aging-related conditionsRF1AG057181 · NIA · MAYO CLINIC JACKSONVILLE · PI KANEKIYO, TAKAHISA · 2018 to 2018
$3.7M
Therapeutic Strategy to Treat Alzheimer's Disease by VGF Delivery into BrainR01AG083981 · NIA · NORTH DAKOTA STATE UNIVERSITY · PI Takahisa Kanekiyo, Jagdish Singh · 2023 to 2026
$2.4M
Neuronal ABCA7 loss of function and Alzheimer’s diseaseRF1AG081203 · NIA · MAYO CLINIC JACKSONVILLE · PI KANEKIYO, TAKAHISA · 2023 to 2023
$2.1M
Enhanced APOE2 Expression into Brain for Therapeutic Strategy for Alzheimer's DiseaseR01AG068034 · NIA · NORTH DAKOTA STATE UNIVERSITY · PI KANEKIYO, TAKAHISA, SINGH, JAGDISH · 2024 to 2025
$1.0M
Endothelial cell senescence and APOE4 in vascular cognitive impairment and dementiaR01AG071226 · NIA · MAYO CLINIC JACKSONVILLE · PI KANEKIYO, TAKAHISA · 2024 to 2025
$775k
NIA NIH HHS R01 AG068034NIA NIH HHS R01 AG071226NIA NIH HHS R01 AG083981NIA NIH HHS RF1 AG057181NIA NIH HHS RF1 AG081203NIA NIH HHS U19 AG069701
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common cause of late-life dementia characterized by progressive neurodegeneration and brain deposition of amyloid-β (Aβ) and phosphorylated tau. The

Indexed as

Alzheimer's diseaseAPOE2Dystrophic neuritesGene therapyNanoparticles

Identifiers

PMID39506961
PMCPMC11538761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.