Evidence map›Paper›PMID 39506920›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2025

Outcome Reporting in Studies Investigating Treatment for Caesarean Scar Ectopic Pregnancy: A Systematic Review.

Simrit Nijjar, Simarjit Sandhar, Ilan E Timor-Tritsch, Andrea Kaelin Agten, Jin Li, Krystle Y Chong, Munira Oza, Rosanna Acklom, Francesco D'Antonio, Lan N Vuong and 4 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simrit NijjarEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.ORCID https://orcid.org/0000-0001-8002-0981
Simarjit SandharEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.
Ilan E Timor-TritschHackensack Meridian School of Medicine, Nutley, New Jersey, USA.
Andrea Kaelin AgtenLiverpool Women's Hospital NHS Foundation Trust, Liverpool, UK.
Jin LiNational Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Krystle Y ChongDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
Munira OzaThe Ectopic Pregnancy Trust, London, UK.
Rosanna AcklomEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.
Francesco D'AntonioCenter for Fetal Care and High-Risk Pregnancy, Department of Obstetrics and Gynecology, University Hospital of Chieti, Chieti, Italy.
Lan N VuongDepartment of Obstetrics and Gynecology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0001-6529-6912
Ben MolDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0001-8337-550X
Cecilia BottomleyEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.
Davor JurkovicEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, UK.
International Collaboration COSCAR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaesarean scar ectopic pregnancy (CSEP) is associated with significant maternal and foetal morbidity. However, the optimal treatment remains unknown.

objectivesThe aim of this study was to review outcomes reported in studies on CSEP treatment and outcome reporting quality. SEARCH STRATEGY: We reviewed 1270 articles identified through searching PubMed, MEDLINE and Google Scholar from 2014 to 2024 using the search terms 'caesarean scar ectopic pregnancy and caesarean scar pregnancy'. SELECTION CRITERIA: We included all study types evaluating any form of CSEP treatment, with a sample size of ≥ 50, where diagnosis was described, and the article was in English. DATA COLLECTION AND ANALYSIS: Two authors independently reviewed studies and assessed outcome reporting and methodological quality. The relationship between outcome reporting quality and publication year and journal type was assessed with univariate and bivariate models. MAIN

resultsA total of 108 studies, including 17 941 women, were included. 83% of all studies originated from China. Studies reported on 326 outcomes; blood loss (86%), need for additional intervention (77%) and time for serum hCG to normalise post treatment (69%) were the most common outcomes. A primary outcome was clearly defined in 11 (10%) studies. The median quality of outcome reporting was 3 (IQR 3-4). No relationship was demonstrated between outcome reporting quality and publication year (p = 0.116) or journal type (p = 0.503).

conclusionsThis review demonstrates that there is a wide variation in outcomes reported in studies on CSEP treatment. Development and implementation of a core outcome set by international stakeholders which includes patients is urgently needed to enable high-quality research that is both useful and relevant to patients.

Indexed as

Cesarean SectionCicatrixPregnancy, EctopicFemaleHumansPregnancyTreatment Outcomecaesarean scar ectopiccore outcome setsoutcome reportingoutcome variation

Identifiers

PMID39506920
PMCPMC11704075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.