Evidence map›Paper›PMID 39506641›Full record

ArticleBMC neuroscience2024

APOE4 rat model of Alzheimer's disease: sex differences, genetic risk and diet.

Bradley Colarusso, Richard Ortiz, Julian Yeboah, Arnold Chang, Megha Gupta, Praveen Kulkarni, Craig F Ferris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bradley Colarusso *Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Richard Ortiz *Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA.
Julian YeboahCenter for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Arnold ChangCenter for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Megha GuptaCenter for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Praveen KulkarniCenter for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Craig F FerrisCenter for Translational NeuroImaging, Northeastern University, Boston, MA, USA. c.ferris@northeastern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The strongest genetic risk factor for Alzheimer's disease (AD) is the ε4 allele of apolipoprotein E (ApoE ε4). A high fat diet also adds to the risk of dementia and AD. In addition, there are sex differences as women carriers have a higher risk of an earlier onset and rapid decline in memory than men. The present study looked at the effect of the genetic risk of ApoE ε4 together with a high fat/high sucrose diet (HFD/HSD) on brain function in male and female rats using magnetic resonance imaging. We hypothesized female carriers would present with deficits in cognitive behavior together with changes in functional connectivity as compared to male carriers. Four-month-old wildtype and human ApoE ε4 knock-in (TGRA8960), male and female Sprague Dawley rats were put on a HFD/HSD for four months. Afterwards they were imaged for changes in function using resting state BOLD functional connectivity. Images were registered to, and analyzed, using a 3D MRI rat atlas providing site-specific data on 173 different brain areas. Resting state functional connectivity showed male wildtype had greater connectivity between areas involved in feeding and metabolism while there were no differences between female and male carriers and wildtype females. The data were unexpected. The genetic risk was overshadowed by the diet. Male wildtype rats were most sensitive to the HFD/HSD presenting with a deficit in cognitive performance with enhanced functional connectivity in neural circuitry associated with food consumption and metabolism.

Indexed as

Alzheimer DiseaseApolipoprotein E4BrainDisease Models, AnimalMagnetic Resonance ImagingRats, Sprague-DawleyRats, TransgenicSex CharacteristicsAnimalsDiet, High-FatFemaleGenetic Predisposition to DiseaseHumansMaleRatsApolipoprotein E4Diffusion weighted imagingFunctional connectivityGraph theoryHigh fat/high sucrose dietMRISex difference

Identifiers

PMID39506641
PMCPMC11539573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.