Evidence map›Paper›PMID 39506629›Full record

ArticleMolecular medicine (Cambridge, Mass.)2024

Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b

Haruki Watanabe, Minakshi Rana, Myoungsun Son, Pui Yan Chiu, Yurong Fei-Bloom, Kwangmin Choi, Betty Diamond, Barbara Sherry

Abstract read
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Splenic PD-L1Research (Washington, D.C.) · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Innate immune training in the neonatal response to sepsis.Molecular medicine (Cambridge, Mass.) · 2025
    Article
  9. Enhanced resistance toFrontiers in pharmacology · 2025
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haruki Watanabe *Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr., Manhasset, NY, 11030, USA.
Minakshi Rana *Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Cornell Medicine, New York, New York, 10021, USA.
Myoungsun SonInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr., Manhasset, NY, 11030, USA.
Pui Yan ChiuInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr., Manhasset, NY, 11030, USA.
Yurong Fei-BloomInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr., Manhasset, NY, 11030, USA.
Kwangmin ChoiDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
Betty DiamondInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr., Manhasset, NY, 11030, USA. bdiamond@northwell.edu.
Barbara SherryInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Dr., Manhasset, NY, 11030, USA. bsherry@northwell.edu.ORCID 0000-0003-3119-1463

Funding

Targeting cognitive and immune impairment in sepsis survivorsP01AI102852 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY, TRACEY, KEVIN J · 2014 to 2018
$11.5M
Mechanisms of polarization of monocytes by DAMPs/PAMPs and C1qR01AI135063 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SON, MYOUNGSUN · 2018 to 2022
$2.1M
National Institute of Allergy and Infectious Diseases P01AI102852National Institute of Allergy and Infectious Diseases R01AI135063NIAID NIH HHS P01 AI102852NIAID NIH HHS R01 AI135063
6 · The paper itself

Abstract

backgroundSepsis survivors exhibit immune dysregulation that contributes to poor long-term outcomes. Phenotypic and functional alterations within the myeloid compartment are believed to be a contributing factor. Here we dissect the cellular and transcriptional heterogeneity of splenic CD11b

methodsSham or CLP surgeries were performed on C57BL/6J and BALB/c mice. Four weeks later splenic CD11b

resultsCD11b

conclusionThe splenic CD11b

Indexed as

Antigens, LyCD11b AntigenMonocytesRNA-SeqSepsisSingle-Cell AnalysisSpleenAnimalsDisease Models, AnimalGene Expression ProfilingMaleMiceMice, Inbred BALB CMice, Inbred C57BLMyeloid CellsTranscriptomeAntigens, LyCD11b AntigenItgam protein, mouseLy-6C antigen, mouseCD11b+Ly6ChighCLPGlycolysisPhagocytosisscRNA-seqSepsis

Identifiers

PMID39506629
PMCPMC11539566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.