Evidence map›Paper›PMID 39506510›Full record

ReviewGenome biology and evolution2024

Diverse Genome Structures among Eukaryotes May Have Arisen in Response to Genetic Conflict.

Elinor G Sterner, Auden Cote-L'Heureux, Xyrus X Maurer-Alcalá, Laura A Katz

Abstract readReview
In one paragraph

Review in Genome biology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Eukaryogenesis From FECA to LECA: Radical Steps Along the Way.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elinor G SternerDepartment of Biological Sciences, Smith College, Northampton, MA 01063, USA.ORCID 0009-0001-4511-9350
Auden Cote-L'HeureuxDepartment of Biological Sciences, Smith College, Northampton, MA 01063, USA.ORCID 0000-0001-5793-7695
Xyrus X Maurer-AlcaláAmerican Museum of Natural History, Department of Invertebrate Zoology, Institute for Comparative Genomics, New York, NY, USA.ORCID 0000-0002-7499-9369
Laura A KatzDepartment of Biological Sciences, Smith College, Northampton, MA 01063, USA.ORCID 0000-0002-9138-4702

Funding

Assessing evolutionary patterns in uncultivable ciliates and their microbiomes by combining single-cell transcriptomics and single-cell genomicsR15HG010409 · NHGRI · SMITH COLLEGE · PI KATZ, LAURA ALINE · 2019 to 2019
$400k
NHGRI NIH HHS R15 HG010409NIH HHS R15HG010409NSF OCE-1924570
6 · The paper itself

Abstract

In contrast to the typified view of genome cycling only between haploidy and diploidy, there is evidence from across the tree of life of genome dynamics that alter both copy number (i.e. ploidy) and chromosome complements. Here, we highlight examples of such processes, including endoreplication, aneuploidy, inheritance of extrachromosomal DNA, and chromatin extrusion. Synthesizing data on eukaryotic genome dynamics in diverse extant lineages suggests the possibility that such processes were present before the last eukaryotic common ancestor. While present in some prokaryotes, these features appear exaggerated in eukaryotes where they are regulated by eukaryote-specific innovations including the nucleus, complex cytoskeleton, and synaptonemal complex. Based on these observations, we propose a model by which genome conflict drove the transformation of genomes during eukaryogenesis: from the origin of eukaryotes (i.e. first eukaryotic common ancestor) through the evolution of last eukaryotic common ancestor.

Indexed as

EukaryotaEvolution, MolecularGenomeAneuploidyChromatinEukaryotic CellsChromatinaneuploidyeukaryogenesisgenetic conflictgenome dynamicsmeiosispolyploidy

Identifiers

PMID39506510
PMCPMC11606643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.