In one paragraphArticle in Anti-cancer agents in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Alexander ShirokovSimbioz Center for the Collective Use of Research Equipment, Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia.ORCID 0000-0003-4321-735X Vyacheslav GrinevSimbioz Center for the Collective Use of Research Equipment, Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia.ORCID 0000-0002-0627-6804 Matvey KanevskiyDepartment of Biochemistry and Biophysics, N.G. Chernyshevsky Saratov National Research State University, Saratov, Russia.ORCID 0000-0002-5932-6748 Yulia FedonenkoDepartment of Biochemistry, Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia.ORCID 0000-0003-0255-8190 Larisa MatoraDepartment of Immunochemistry, Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), Saratov, Russia.ORCID 0000-0001-5654-8292 Natalya PolukonovaDepartment of General Biology, Pharmacognosy and Botany, Saratov State Medical University, n.a. V.I. Razumovsky, Saratov, Russia.ORCID 0000-0001-9228-6808 Dmitry MudrakDepartment of Pathological Anatomy, Saratov State Medical University, n.a. V.I. Razumovsky, Saratov, Russia.ORCID 0000-0001-7399-9204 Artyom MylnikovDepartment of Pathological Anatomy, Saratov State Medical University, n.a. V.I. Razumovsky, Saratov, Russia.ORCID 0000-0003-2433-8228 Anna PolukonovaDepartment of General Biology, Pharmacognosy and Botany, Saratov State Medical University, n.a. V.I. Razumovsky, Saratov, Russia.ORCID 0000-0001-7198-1254 Alla BucharskayaCenter of Collective Use of Experimental Oncology, Saratov State Medical University, N.A.V.I. Razumovsky, Saratov, Russia.ORCID 0000-0003-0503-6486 Nikita NavolokinDepartment of Pathological Anatomy, Saratov State Medical University, n.a. V.I. Razumovsky, Saratov, Russia.ORCID 0000-0001-7876-9758 Galina MaslyakovaDepartment of Pathological Anatomy, Saratov State Medical University, n.a. V.I. Razumovsky, Saratov, Russia.ORCID 0000-0001-8834-1536 Funding
Ministry of Health of the Russian Federation SSMU-2021-003Ministry of Science and Higher Education of the Russian Federation 1022040600860-5
6 · The paper itselfAbstract
introduction
methodsThe
resultsTwo antitumor-active fractions of a flavonoid nature were isolated and chromatographically purified. On the basis of the nuclear magnetic resonance data, the aglycone fragment of the main component of one fraction was found to be structured as 2-(3,4-dimethoxyphenyl)-7-hydroxychroman-4-one, or 3',4'-dimethoxy-7- hydroxyflavanone.
conclusionThe antitumor effect of the most active fraction containing 7-O-glucoside of apigenin, glycoside 7,3'-di-O-luteolin and trace amounts of eupatilin against renal carcinoma A498 cells was manifested in its cytotoxic, cytostatic, apoptotic and autophagosomal activities. In addition, we found 3-(1-2)-glucoside of soyaspogenol B, which is a pentacyclic triterpenoid in the structure.
Indexed as
Antineoplastic Agents, PhytogenicFlavonoidsPlant ExtractsCell Line, TumorCell ProliferationChromatography, High Pressure LiquidDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureAntineoplastic Agents, PhytogenicFlavonoidsPlant ExtractsA498 renal carcinomaapoptotic activitycircular dichroism (CD) analysiscytotoxic activityflavonoid fractionsFTIR analysisGratiola officinalis L.HPLC-ESI-MS/MSnuclear magnetic resonance (NMR) analysis.plant extract
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