Evidence map›Paper›PMID 39506415›Full record

ArticleJournal of developmental origins of health and disease2024

Maternal under-nutrition during pregnancy alters the molecular response to over-nutrition in multiple organs and tissues in nonhuman primate juvenile offspring.

Laura A Cox, Sobha Puppala, Jeannie Chan, Angelica M Riojas, Kenneth J Lange, Shifra Birnbaum, Edward J Dick, Anthony G Comuzzie, Mark J Nijland, Cun Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of developmental origins of health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura A CoxCenter for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0002-8836-3783
Sobha PuppalaCenter for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jeannie ChanCenter for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Angelica M RiojasDepartment of Radiology, University of Texas Health Science Center, San Antonio, TX, USA.
Kenneth J LangeSouthwest Research Institute, San Antonio, TX, USA.
Shifra BirnbaumSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Edward J DickSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Anthony G ComuzzieThe Obesity Society, Rockville, MD, USA.
Mark J NijlandUniversity of the Incarnate Word, San Antonio, TX, USA.ORCID https://orcid.org/0000-0003-0998-8804
Cun LiDepartment of Animal Sciences, University of Wyoming, Laramie, WY, USA.
Peter W NathanielszSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Michael OlivierCenter for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Womb to Tomb: Developmental Programming and Aging Interactions in PrimatesU19AG057758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CLARKE, GEOFFREY DAVID, COX, LAURA A · 2018 to 2024
$13.2M
NIA NIH HHS U19 AG057758NIH HHS P51 OD011133
6 · The paper itself

Abstract

Previous studies in rodents suggest that mismatch between fetal and postnatal nutrition predisposes individuals to metabolic diseases. We hypothesized that in nonhuman primates (NHP), fetal programming of maternal undernutrition (MUN) persists postnatally with a dietary mismatch altering metabolic molecular systems that precede standard clinical measures. We used unbiased molecular approaches to examine response to a high fat, high-carbohydrate diet plus sugar drink (HFCS) challenge in NHP juvenile offspring of MUN pregnancies compared with controls (CON). Pregnant baboons were fed

Indexed as

MalnutritionMaternal Nutritional Physiological PhenomenaPapioPrenatal Exposure Delayed EffectsAnimalsFemaleFetal DevelopmentLiverMaleOvernutritionPregnancyDevelopmental programmingintrauterine growth restrictionnonhuman primatewestern diet

Identifiers

PMID39506415
PMCPMC11686573

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.