Dimensions of childhood adversity differentially affect autonomic nervous system coordination in response to stress.
Meredith A Gruhn, Rachel E Siciliano, Allegra S Anderson, Allison Vreeland, Lauren M Henry, Kelly H Watson, George M Slavich, Jon Ebert, Tarah Kuhn, Bruce E Compas
Article in Stress (Amsterdam, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Meredith A GruhnDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-5523-8871
Rachel E SicilianoDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Allegra S AndersonDepartment of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.
Allison VreelandDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Lauren M HenryNeuroscience and Novel Therapeutics Unit, National Institute of Mental Health, Bethesda, MD, USA.
Kelly H WatsonDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0001-5710-3818
Jon EbertDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Tarah KuhnDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Bruce E CompasDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Funding
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Postdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5M
Traumatic Stress Across the Lifespan: A Biopsychosocial Training ProgramT32MH018869 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CARLA KMETT DANIELSON, DEAN Gaines KILPATRICK · 1988 to 2026
$7.2M
LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
The Impact of Adversity on Neurobiological and Psychosocial Dimensions of the Stress Response SystemK23MH134136 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Meredith Gruhn · 2024 to 2026
$557k
Adverse Childhood Experiences, Adolescent and Caregiver Emotion Regulation, and Adolescent Physical and Mental HealthR21HD098454 · NICHD · VANDERBILT UNIVERSITY · PI COMPAS, BRUCE E · 2019 to 2020
$388k
Child Maltreatment and the Stress Response System: Integrating Dimensions of Biological and Psychological Responses to Stress in AdolescenceF31MH115669 · NIMH · VANDERBILT UNIVERSITY · PI GRUHN, MEREDITH · 2018 to 2019
It is well-established that disrupted autonomic nervous system (ANS) reactivity exacerbates risk for long-term maladjustment following childhood adversity (CA). However, few studies have integrated measures of both the sympathetic (SNS) and parasympathetic (PNS) branches of the ANS, resulting in a unidimensional understanding of ANS functioning as a mechanism of risk. Further, past work has primarily measured CA only at the aggregate level (e.g. "total CA"), necessitating further research to accurately characterize this risk pathway. The present study examines how CA, measured cumulatively and dimensionally (i.e. CA characterized by threat versus deprivation), moderates the association between the SNS and PNS at rest and in response to acute social and nonsocial stressors. Participants included 97 adolescents ages 10-15 (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dimensions of childhood adversity differentially affect autonomic nervous system coordination in response to stress. · full record | OpenQuestion