Evidence map›Paper›PMID 39506350›Full record

ArticlePharmacology research & perspectives2024

Pharmacokinetics and brain uptake of sodium selenate and selenium in naïve rats and a lateral fluid percussion injury rat model.

Chenxu Li, Pablo M Casillas-Espinosa, Patricia Grandizoli Saletti, Tina Chi, Glenn Yamakawa, Juliana Silva, Matt Hudson, Wei Liu, Nigel C Jones, Sandy R Shultz and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chenxu LiCollege of Pharmacy, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Pablo M Casillas-EspinosaDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Patricia Grandizoli SalettiLaboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Tina ChiCollege of Pharmacy, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Glenn YamakawaDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Juliana SilvaDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Matt HudsonDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Wei LiuLaboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Nigel C JonesDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Sandy R ShultzDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Idrish AliDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Usha MishraCollege of Pharmacy, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
James C CloydCollege of Pharmacy, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Solomon L MosheLaboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Aristea S GalanopoulouLaboratory of Developmental Epilepsy, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Terence J O'BrienDepartment of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Lisa D ColesCollege of Pharmacy, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-3613-9904

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
Translational Platform for Epilepsy Therapy and Biomarker DiscoveryR01NS127524 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Denes V. Agoston, LISA D COLES · 2022 to 2026
$11.0M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
NICHD NIH HHS P50 HD105352NINDS NIH HHS R01 NS127524NINDS NIH HHS U54 NS100064NINDS NIH HHS U54-NS100064
6 · The paper itself

Abstract

Post-traumatic epilepsy (PTE) is a life-long complication of traumatic brain injury (TBI). The development of PTE is associated with neurological morbidity and increases the risk of mortality. An aim of EpiBioS4Rx (Epilepsy Bioinformatics Study for Antiepileptogenic Therapy) was to test potential therapies to prevent the development of PTE in the lateral fluid percussion injury (LFPI) rat model of TBI, in which rats were subjected to injury at the left parietal cortex. Sodium selenate has been reported to be antiepileptogenic post-TBI in rodent models by activating protein phosphatase 2A and reducing phosphorylated tau (p-tau) protein. We aimed to characterize the pharmacokinetics (PK) and brain uptake of sodium selenate using naïve control and LFPI rats. Rats received either a single bolus dose or a single bolus dose followed by a 7-day subcutaneous minipump infusion of sodium selenate. Sodium selenate and selenium concentrations in plasma and brain were analyzed and used for PK estimation and brain exposure assessment. Selenium concentrations rapidly increased after sodium selenate administration, demonstrating biotransformation from sodium selenate to selenium. Sodium selenate and selenium PK parameters were estimated using non-compartmental analysis. Sodium selenate clearance (CL/F) and volume of distribution (V

Indexed as

BrainBrain Injuries, TraumaticDisease Models, AnimalRats, Sprague-DawleySelenic AcidSeleniumAnimalsAnticonvulsantsBlood-Brain BarrierMaleRatsAnticonvulsantsSelenic AcidSeleniumantiepileptogenesisblood–brain barrierpharmacokineticspost‐traumatic epilepsytraumatic brain injury

Identifiers

PMID39506350
PMCPMC11540874

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.