ArticleNature2024
Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed.
- AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes.Nature methods · 2026Article
- Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival.Nature genetics · 2026Article
- Single-cell epigenomics of colorectal cancer.Experimental & molecular medicine · 2026Review
- Article
- Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Molecular cancer · 2026Review
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Quantitative and sensitive neuroblastoma minimal residual disease detection using extrachromosomal DNA (ecDNA) breakpoints.bioRxiv : the preprint server for biology · 2026Article
- BRD4: From molecular understanding to therapeutics development.Molecular cell · 2026Review
- Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.Nature reviews. Urology · 2026Review
- Origins and consequences of oncogenic 3D chromatin remodelling.Nature reviews. Cancer · 2026Review
- Exploring the landscape of targetable alterations in patients with glioblastoma.Nature reviews. Clinical oncology · 2026Review
- Plasticity of extrachromosomal DNA segregation during drug adaptation.Nature communications · 2026Article
- scAmp enables focal gene amplification analysis from single-cell data.Nature communications · 2026Article
- Examining the role of extrachromosomal DNA in lung cancer.Journal of the National Cancer Institute · 2026Article
- Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.Genome research · 2026Article
- Multiomic profiling links L1 retrotransposition to genomic instability and ecDNA in bladder cancer.Nature communications · 2026Article
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
- Cis and trans regulatory mechanisms of extrachromosomal DNA segregation.Nature cell biology · 2026Article
- Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer.Journal of personalized medicine · 2026Review
- A bibliometric analysis of extrachromosomal DNA in cancer over six decades.Discover oncology · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
25 authors.
King L Hung *Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3662-4662
Matthew G Jones *Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
Ivy Tsz-Lo Wong *Sarafan ChEM-H, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9761-3422
Ellis J Curtis *Sarafan ChEM-H, Stanford University, Stanford, CA, USA.
Joshua T LangeSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Britney Jiayu HeCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8989-1521
Jens LuebeckDepartment of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.ORCID 0000-0003-4391-979X
Rachel SchmargonExperimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0009-0009-3535-7185
Elisa ScanuDepartment of Mathematics, Queen Mary University of London, London, UK.
Lotte BrücknerExperimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6155-2277
Xiaowei YanCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4846-8812
Rui LiCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
Aditi GnanasekarSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Rocío Chamorro GonzálezExperimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-5653-7259
Julia A BelkCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4724-6158
Zhonglin LiuDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Bruno MelilloDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0000-0002-9708-5287
Vineet BafnaDepartment of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.
Jan R DörrExperimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.
Benjamin WernerEvolutionary Dynamics Group, Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-6857-8699
Weini HuangDepartment of Mathematics, Queen Mary University of London, London, UK.ORCID 0000-0002-9016-2665
Benjamin F CravattDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.ORCID 0000-0001-5330-3492
Anton G HenssenExperimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-1534-778X
Paul S MischelSarafan ChEM-H, Stanford University, Stanford, CA, USA. pmischel@stanford.edu.ORCID 0000-0002-4560-2211
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. howchang@stanford.edu.ORCID 0000-0002-9459-4393
Funding
eDyNAmiC - STANFORDOT2CA278688 · NCI · STANFORD UNIVERSITY · PI PAUL S MISCHEL · 2022 to 2026
$7.7MLncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4MSoftware and algorithms for elucidating the structure, function, and evolution of extrachromosomal DNAU24CA264379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, MESIROV, JILL P. · 2021 to 2025
$3.5MComputational methods for detecting patterns of complex genomic variationR01GM114362 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2016 to 2026
$3.1MProgram in Translational and Experimental HematologyT32HL120824 · NHLBI · STANFORD UNIVERSITY · PI MAJETI, RAVINDRA · 2014 to 2023
$2.4MeDyNAmiC - SCRIPPSOT2CA278692 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI BENJAMIN F CRAVATT · 2022 to 2026
$2.1MeDyNAmiC - UCSDOT2CA278635 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2022 to 2026
$1.8MQuantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumorsK99CA286968 · NCI · STANFORD UNIVERSITY · PI JONES, MATTHEW GREGORY · 2024 to 2025
$335keDyNAmiC-QMULOT2CA278670 · NCI · UNIV/LONDON-QUEEN MARY& WESTFIELD COLL · PI HUANG, WEINI · 2022 to 2024
$301keDyNAmiC - CHARITEOT2CA278644 · NCI · CHARITE, UNIVERSITAETSMEDIZIN BERLIN · PI HENSSEN, ANTON GEORGE · 2022 to 2024
$214kRegulation and retention of extrachromosomal oncogene amplifications in cancerF99CA274692 · NCI · STANFORD UNIVERSITY · PI HUNG, KING L. · 2022 to 2023
$82kCancer Research UK CGCATF-2021/100012NCI NIH HHS F99 CA274692NCI NIH HHS K99 CA286968NCI NIH HHS OT2 CA278635NCI NIH HHS OT2 CA278644NCI NIH HHS OT2 CA278670NCI NIH HHS OT2 CA278688NCI NIH HHS OT2 CA278692NCI NIH HHS R35 CA209919NCI NIH HHS U24 CA264379NHLBI NIH HHS T32 HL120824NIGMS NIH HHS R01 GM114362
Abstract
The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently
Indexed as
DNAExtrachromosomal InheritanceMitosisNeoplasmsCell Line, TumorEpigenesis, GeneticGene DosageHumansModels, GeneticOncogenesSingle-Cell AnalysisTranscription, GeneticDNA
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.