ArticleNature2024
Immune responses in checkpoint myocarditis across heart, blood and tumour.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed.
- The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact.Journal of immunotherapy and precision oncology · 2026Review
- Immune Hallmarks of Recurrent Immune Checkpoint Inhibitor-Mediated Inflammatory Arthritis.Cancer immunology research · 2026Article
- Spatial Transcriptomics and Mechanisms of Immune Checkpoint Inhibitor-Associated Interstitial Nephritis.Kidney international reports · 2026Article
- MMP12 induces fibrogenic macrophage differentiation to drive granuloma-associated cardiac fibrosis.American journal of respiratory and critical care medicine · 2026Article
- A serum proteomics-based predictive model for steroid-resistant immune checkpoint inhibitor associated myocarditis.Clinical and translational medicine · 2026Article
- The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Immune Checkpoint Inhibitor-Associated Acute Kidney Injury: A Report from the 34th Acute Disease Quality Initiative (ADQI) Consensus Conference.Journal of the American Society of Nephrology : JASN · 2026Article
- The Cardio-Onco-Immune Axis: immunopathological mechanisms in the cardiac microenvironment of checkpoint inhibitor-induced myocarditis.Acta pharmacologica Sinica · 2026Review
- Reversing the pipeline: a 'human-first' multi-omics approach to cardiovascular discovery.Experimental & molecular medicine · 2026Review
- Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditis.Science advances · 2026Article
- Endomyocardial Biopsies in the Diagnostic Workup of Immune Checkpoint Inhibitor Associated Myocarditis.Current heart failure reports · 2026Review
- Identification and validation of blood leukocyte DNA methylation biomarkers for early detection of colorectal neoplasm.Chinese medical journal · 2026Article
- Cardiac-targeting peptide-modified Prussian blue nanozymes loaded with Astragaloside IV for efficient ICI-myocarditis therapy.Materials today. Bio · 2026Article
- PD-1/PD-L1 Signaling in Non-ICI Myocarditis.JACC. Basic to translational science · 2026Article
- Neoadjuvant BO-112 and Hypofractionated Radiation Therapy with or without Nivolumab in Soft-Tissue Sarcoma: Preclinical and Phase I Results.Cancer discovery · 2026Article
- IL-6 receptor blockade impedes proinflammatory atypical Treg subset associated with immune checkpoint inhibitor-induced inflammatory arthritis.The Journal of clinical investigation · 2026Article
- Comprehensive characterization of the inflammatory ecosystems in immunotherapy-induced adverse events versus chronic inflammatory diseases.Journal for immunotherapy of cancer · 2026Article
- Heterogeneity of macrophages in PD-1/PD-L1 inhibitor therapy: a single-cell perspective.Cellular & molecular biology letters · 2026Review
- IL-6 in Checkpoint Myocarditis: A Promising Biomarker and Therapeutic Target.JACC. CardioOncology · 2026Article
- Immune Profiling Identifies Inflammatory Signatures in Immune Checkpoint Inhibitor-Related Myocarditis.JACC. CardioOncology · 2026Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
40 authors.
Steven M Blum *Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Daniel A Zlotoff *Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Neal P Smith *Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1394-3158
Isabela J Kernin *Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Swetha Ramesh *Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7833-165X
Leyre ZubiriCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Joshua CaplinCardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nandini SamantaCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Sidney MartinCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mike WangMass General Cancer Center, Boston, MA, USA.ORCID 0000-0001-6487-5912
Alice TirardCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Yuhui SongKrantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5087-4684
Katherine H XuKrantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jaimie BarthDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Pritha SenCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kamil SlowikowskiCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jessica TantivitCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-2179-0377
Kasidet ManakongtreecheepCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Benjamin Y ArnoldCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mazen NasrallahCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Christopher J PintoMass General Cancer Center, Boston, MA, USA.
Daniel McLoughlinMass General Cancer Center, Boston, MA, USA.ORCID 0000-0002-3697-9623
Monica JacksonMass General Cancer Center, Boston, MA, USA.
PuiYee ChanMass General Cancer Center, Boston, MA, USA.
Aleigha LawlessKrantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
William A MichaudKrantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3664-2094
Tatyana SharovaKrantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Linda T NiemanHarvard Medical School, Boston, MA, USA.
Justin F GainorMass General Cancer Center, Boston, MA, USA.ORCID 0000-0001-8697-4081
Catherine J WuBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Dejan JuricMass General Cancer Center, Boston, MA, USA.ORCID 0000-0003-2983-7704
Mari Mino-KenudsonHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-9092-2265
Giacomo OliveiraBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7435-5603
Ryan J SullivanMass General Cancer Center, Boston, MA, USA.ORCID 0000-0001-5344-6645
Genevieve M BolandBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID 0000-0002-7522-6173
James R StoneHarvard Medical School, Boston, MA, USA.
Molly F ThomasCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1393-6559
Tomas G NeilanHarvard Medical School, Boston, MA, USA.
Kerry L ReynoldsMass General Cancer Center, Boston, MA, USA.
Alexandra-Chloé VillaniCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. avillani@mgh.harvard.edu.ORCID 0000-0001-7461-0408
Funding
Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI David McDermott · 2003 to 2026
$53.4MDana Farber/Harvard Cancer Consortium Career Development Program in Clinical OncologyK12CA087723 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Tsai Ting · 2002 to 2026
$17.9MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MRESEARCH TRAINING IN DIGESTIVE DISEASES AND NUTRITIONT32DK007191 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1986 to 2026
$14.6MTraining Program in Cancer Biology and TherapeuticsT32CA071345 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel A. Haber, Lecia V. Sequist · 1997 to 2026
$10.6MResearch Training in Rheumatology at Massachusetts General HospitalT32AR007258 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1986 to 2026
$6.9MSTOP-CA: Statins to prevent Cardiotoxicity from AnthracyclinesR01HL130539 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G, SCHERRER-CROSBIE, MARIELLE · 2016 to 2020
$3.2MPatho-Genetic Analysis of Invasive Mucinous Adenocarcinoma of the LungR01CA240317 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI MAEDA, YUTAKA, SNYDER, ERIC LEE · 2020 to 2024
$3.1MMechanisms of Cardiac Dysfunction in HIV and the Effect of StatinsR01HL137562 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G, ZANNI, MARKELLA V. · 2017 to 2020
$2.7MDeciphering the Achilles Heel of Cancer ImmunotherapyDP2CA247831 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VILLANI, ALEXANDRA-CHLOE · 2019 to 2019
$2.5MDecoding T cell clonotypes, biology and predictive biomarkers associated with immune checkpoint MyocarditisR01AI182098 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Alexandra-Chloe Villani · 2025 to 2026
$1.7MHigh-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantationK08HL157725 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SEN, PRITHA · 2021 to 2025
$929kNCI NIH HHS DP2 CA247831NCI NIH HHS K12 CA087723NCI NIH HHS P50 CA101942NCI NIH HHS R01 CA240317NCI NIH HHS T32 CA071345NHLBI NIH HHS K08 HL157725NHLBI NIH HHS K24 HL150238NHLBI NIH HHS R01 HL130539NHLBI NIH HHS R01 HL137562NHLBI NIH HHS T32 HL007208NIAID NIH HHS K08 AI197864NIAID NIH HHS R01 AI182098NIAMS NIH HHS T32 AR007258NIDDK NIH HHS K08 DK127246NIDDK NIH HHS T32 DK007191
Abstract
Immune checkpoint inhibitors are widely used anticancer therapies
Indexed as
BloodImmune Checkpoint InhibitorsMyocarditisMyocardiumNeoplasmsAgedAutoantigensBiomarkersB-LymphocytesCase-Control StudiesCell LineageDendritic CellsFemaleFibroblastsHeartHumansAutoantigensBiomarkersImmune Checkpoint InhibitorsReceptors, Antigen, T-CellTroponin ITroponin TVentricular Myosins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.