Evidence map›Paper›PMID 39506105›Full record

ArticleNature2025

A mechanism for hypoxia-induced inflammatory cell death in cancer.

Abhishek Bhardwaj, Maria C Panepinto, Beatrix Ueberheide, Benjamin G Neel

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abhishek BhardwajLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA. abhishek.bhardwaj@nyulangone.org.ORCID 0000-0003-4539-7497
Maria C PanepintoLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-7040-8181
Beatrix UeberheideLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
Benjamin G NeelLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
SIGNAL TRANSDUCTION BY NON-TRANSMEMBRANE PTPSR01CA049152 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEEL, BENJAMIN G. · 1989 to 2020
$4.4M
Molecular ontology of drug tolerant persisters in HER2 positive breast cancer - Resubmission - 1R01CA264933 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BENJAMIN G. NEEL, Jane Amanda Skok · 2022 to 2026
$3.5M
NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA049152NCI NIH HHS R01 CA264933
6 · The paper itself

Abstract

Hypoxic cancer cells resist many antineoplastic therapies and can seed recurrence

Indexed as

Breast NeoplasmsDeubiquitinating Enzyme CYLDInflammasomesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinProtein Tyrosine Phosphatase, Non-Receptor Type 1Tumor HypoxiaAdenosine TriphosphatasesAnimalsCell DeathCell Line, TumorEndoplasmic Reticulum StressFemaleHumansInflammationMiceABL1 protein, humanAdenosine TriphosphatasesARG tyrosine kinaseCYLD protein, humanDeubiquitinating Enzyme CYLDInflammasomesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanProteinsProtein-Tyrosine KinasesProtein Tyrosine Phosphatase, Non-Receptor Type 1Proto-Oncogene Proteins c-ablPTPN1 protein, humanRNF213 protein, humanSPATA2 protein, humanUbiquitin-Protein Ligases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.