Evidence map›Paper›PMID 39506104›Full record

ArticleNature2024

Identification and genetic dissection of convergent persister cell states.

Sydney B Blattman, Wenyan Jiang, E Riley McGarrigle, Menghan Liu, Panos Oikonomou, Saeed Tavazoie

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Characterization of Antibiotic-Tolerant Persister Cells inAnimals : an open access journal from MDPI · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sydney B BlattmanDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Wenyan JiangDepartment of Biological Sciences, Columbia University, New York, NY, USA.
E Riley McGarrigleDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0009-0002-9701-6078
Menghan LiuDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Panos OikonomouDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0001-7387-0312
Saeed TavazoieDepartment of Biological Sciences, Columbia University, New York, NY, USA. st2744@columbia.edu.ORCID 0000-0003-2183-4162

Funding

Systems biological interrogation of bacterial persistenceR01AI077562 · NIAID · PRINCETON UNIVERSITY · PI TAVAZOIE, SAEED F · 2010 to 2024
$6.4M
Stochastic tuning: a novel regulatory mechanism for cellular adaptationR01GM139215 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TAVAZOIE, SAEED F · 2020 to 2023
$1.6M
New CRISPR tools for systematic interrogation of genetic and transcriptional determinants of antibiotic sensitivity in bacteriaR00AI153530 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JIANG, WENYAN · 2023 to 2024
$498k
New CRISPR tools for systematic interrogation of genetic and transcriptional determinants of antibiotic sensitivity in bacteriaK99AI153530 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI JIANG, WENYAN · 2021 to 2022
$210k
NIAID NIH HHS K99 AI153530NIAID NIH HHS R00 AI153530NIAID NIH HHS R01 AI077562NIGMS NIH HHS R01 GM139215
6 · The paper itself

Abstract

Persister cells, rare phenotypic variants that survive normally lethal levels of antibiotics, present a major barrier to clearing bacterial infections

Indexed as

Drug Resistance, BacterialEscherichia coliSingle-Cell AnalysisAnti-Bacterial AgentsClustered Regularly Interspaced Short Palindromic RepeatsEndodeoxyribonucleasesEscherichia coli ProteinsGene Expression Regulation, BacterialMicrobial ViabilityProtease LaProtein BiosynthesisRNA, BacterialRNA-SeqTranscription, GeneticAnti-Bacterial AgentsEndodeoxyribonucleasesEscherichia coli ProteinsLon protein, E coliProtease LaRNA, BacterialYqgF protein, E coli

Identifiers

PMID39506104
PMCPMC11634777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.