Evidence map›Paper›PMID 39506084›Full record

ArticleCommunications biology2024

KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes.

Andrew Wang, Anna-Marie Fairhurst, Kui Liu, Benjamin Wakeland, Spencer Barnes, Venkat S Malladi, Kasthuribai Viswanathan, Carlos Arana, Igor Dozmorov, Amrita Singhar and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Andrew WangDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Anna-Marie FairhurstDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kui LiuDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Benjamin WakelandDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Spencer BarnesDepartment of Bioinformatics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Venkat S MalladiDepartment of Bioinformatics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-0144-0564
Kasthuribai ViswanathanDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Carlos AranaDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Igor DozmorovDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amrita SingharDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yong DuDepartment of Biomedical Engineering, University of Houston, Houston, TX, USA.
Marjaan ImamDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Angela MosesDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0009-3211-4356
Christian ChenDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ashwini SunkavalliDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jose CascoDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dinesh RakhejaDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-6888-7902
Quan-Zhen LiDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chandra MohanDepartment of Biomedical Engineering, University of Houston, Houston, TX, USA.
Carol ClaybergerFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Edward K WakelandDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shaheen KhanDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. shaheenmkhan@outlook.com.ORCID 0009-0008-7691-9810

Funding

Defining genetic pathways to severe systemic autoimmunityR01AI069371 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI WAKELAND, EDWARD K. · 2006 to 2010
$2.9M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) 5R01AI069371NIAID NIH HHS R01 AI069371
6 · The paper itself

Abstract

Although significant progress has been achieved in elucidating the genetic architecture of systemic lupus erythematosus (SLE), identifying genes underlying the pathogenesis has been challenging. The NZM2410-derived lupus susceptibility Sle3 locus is associated with T cell hyperactivity and activated myeloid cells. However, candidate genes associated with these phenotypes have not been identified. Here, we narrow the Sle3 locus to a smaller genomic segment (Sle3k) and show that mice carrying Sle3k and Sle1 loci developed lupus nephritis. We identify Klf13 as the primary candidate gene that is associated with genome-wide transcription changes resulting in higher levels of proinflammatory cytokines, enhanced T cell activation, and hyperresponsiveness of myeloid cells. Correspondingly, Klf13

Indexed as

ChromatinCytokinesLupus Erythematosus, SystemicMice, KnockoutAnimalsCell Cycle ProteinsChemokine CCL5FemaleGenetic Predisposition to DiseaseKruppel-Like Transcription FactorsLupus NephritisMiceMice, Inbred C57BLMyeloid CellsRepressor ProteinsT-LymphocytesCell Cycle ProteinsChemokine CCL5ChromatinCytokinesKlf13 protein, mouseKruppel-Like Transcription FactorsRepressor Proteins

Identifiers

PMID39506084
PMCPMC11541912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.