Evidence map›Paper›PMID 39505986›Full record

ArticleScientific reports2024

FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway.

Fang Zhao, Dongyang Xu, Xiumei Wang, Xiaofeng Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fang ZhaoDepartment of Stomatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Dongyang XuDepartment of Stomatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiumei WangDepartment of Stomatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. hrbwangmei@163.com.
Xiaofeng WangDepartment of Stomatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. 13633617656@163.com.

Funding

National Natural Science Foundation of China 8167110215
6 · The paper itself

Abstract

This study first investigated how FNDC5 affected the development of oral cancer and revealed the role of FNDC5 in the migration and invasion of oral cancer. The present work evaluated differential FNDC5 expression within oral cancer samples versus matched non-carcinoma samples based on GEO database analysis and immunohistochemistry. We then generated oral cancer cell lines with FNDC5 overexpression and knockdown to determine the role of altered FNDC5 expression in the migration and invasion of oral cancer. PI3K inhibitor was used for investigating the possible mechanism underlying FNDC5 during EMT of oral cancer. Finally, these in-vitro results were validated using the lung metastatic nude mouse model. According to our results, FNDC5 level markedly decreased within oral cancer compared with adjacent samples and FNDC5 overexpression inhibited migration, invasion as well as EMT of oral cancer, while FNDC5 knockdown promoted oral cancer cell EMT. In addition, PI3K inhibitors blocked the induction of oral cancer cells EMT by FNDC5 knockdown. In vivo experiments further demonstrated the above results. This work is the first to illustrate the impact of FNDC5 on inhibiting migration and invasion of oral cancer, and our results suggest that FNDC5 affects EMT of oral cancer via the inhibition of PI3K/Akt/Snail pathway.

Indexed as

Cell MovementEpithelial-Mesenchymal TransitionFibronectinsMouth NeoplasmsNeoplasm InvasivenessPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionSnail Family Transcription FactorsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceFibronectinsFNDC5 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSnail Family Transcription FactorsEpithelial–mesenchymal transitionFNDC5Invasion and migrationOral cancerPI3K/Akt/Snail pathway

Identifiers

PMID39505986
PMCPMC11542081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.