Evidence map›Paper›PMID 39505971›Full record

ArticleScientific reports2024

ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.

Mateusz Olbromski, Monika Mrozowska, Beata Smolarz, Hanna Romanowicz, Agnieszka Rusak, Aleksandra Piotrowska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mateusz OlbromskiDepartment of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Chalubinskiego 6a, Wroclaw, 50-368, Poland. mateusz.olbromski@umw.edu.pl.
Monika MrozowskaDepartment of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Chalubinskiego 6a, Wroclaw, 50-368, Poland.
Beata SmolarzDepartment of Pathology, Polish Mother's Memorial Hospital Research Institute, 281/289 Rzgowska St, Lodz, 93-338, Poland.
Hanna RomanowiczDepartment of Pathology, Polish Mother's Memorial Hospital Research Institute, 281/289 Rzgowska St, Lodz, 93-338, Poland.
Agnieszka RusakDepartment of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Chalubinskiego 6a, Wroclaw, 50-368, Poland.
Aleksandra PiotrowskaDepartment of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Chalubinskiego 6a, Wroclaw, 50-368, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the leading cause of death among cancer patients worldwide. In 2020, almost 12% of all cancers were diagnosed with BC. Therefore, it is important to search for new potential markers of cancer progression that could be helpful in cancer diagnostics and successful anti-cancer therapies. In this study, we investigated the potential role of the lysine acetyltransferases KAT6A and KAT6B in the outcome of patients with invasive breast carcinoma. The expression profiles of KAT6A/B in 495 cases of IDC and 38 cases of mastopathy (FBD) were examined by immunohistochemistry. KAT6A/B expression was also determined in the breast cancer cell lines MCF-7, BT-474, SK-BR-3, T47D, MDA-MB-231, and MDA-MB-231/BO2, as well as in the human epithelial mammary gland cell line hTERT-HME1 - ME16C, both at the mRNA and protein level. Statistical analysis of the results showed that the nuclear expression of KAT6A/B correlates with the estrogen receptor status: KAT6A

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastEstrogen Receptor alphaHistone AcetyltransferasesAdultAgedCell Line, TumorFemaleGene Expression Regulation, NeoplasticHistone DeacetylasesHumansLysineMCF-7 CellsMiddle AgedESR1 protein, humanEstrogen Receptor alphaHistone AcetyltransferasesHistone DeacetylasesKAT6A protein, humanKAT6B protein, humanLysine

Identifiers

PMID39505971
PMCPMC11541733

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.