Evidence map›Paper›PMID 39505816›Full record

ReviewCurrent topics in behavioral neurosciences2025

Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder and Generalized Anxiety Disorder.

Samantha L Cilli, Miriam A Goldberg, Camila Cosmo, Amanda R Arulpragasam, Amin Zand Vakili, Yosef A Berlow, Noah S Philip

Abstract readReview
In one paragraph

Review in Current topics in behavioral neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samantha L CilliCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA.
Miriam A GoldbergCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA.
Camila CosmoCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA.
Amanda R ArulpragasamCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA.
Amin Zand VakiliCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA.
Yosef A BerlowCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA.
Noah S PhilipCenter for Neurorestoration and Neurotechnology, VA Providence Healthcare System, Providence, RI, USA. Noah_Philip@Brown.edu.

Funding

Neuroimaging and Neuromodulation CoreP20GM130452 · NIGMS · BUTLER HOSPITAL (PROVIDENCE, RI) · PI JONES, RICHARD N · 2019 to 2023
$11.3M
Mechanistic circuit markers of transcranial magnetic stimulation outcomes in pharmacoresistant depressionR01MH120126 · NIMH · STANFORD UNIVERSITY · PI WILLIAMS, LEANNE · 2019 to 2023
$3.4M
VA RR&D Center for Neurorestoration and NeurotechnologyI50RX002864 · VA · PROVIDENCE VA MEDICAL CENTER · PI BENJAMIN D GREENBERG, LEIGH R HOCHBERG · 2018 to 2026
–
Developing Computational Nosologies of Posttraumatic Stress Disorder (PTSD)IK2CX002115 · VA · PROVIDENCE VA MEDICAL CENTER · PI ZAND VAKILI, AMIN · 2021 to 2025
–
Modeling the Treatment Response of Transcranial Magnetic Stimulation for DepressionIK2CX002603 · VA · PROVIDENCE VA MEDICAL CENTER · PI Yosef Alfred Berlow · 2024 to 2026
–
CSRD VA I01 CX002088CSRD VA IK2 CX002115CSRD VA IK2 CX002603NIGMS NIH HHS P20 GM130452NIMH NIH HHS R01 MH120126RRD VA I50 RX002864
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) are debilitating psychiatric disorders. While treatments are often effective, many patients do not adequately respond or experience significant side effects. Transcranial magnetic stimulation (TMS) is an emerging approach for treating PTSD and GAD. Several randomized clinical trials have demonstrated that TMS over the dorsolateral prefrontal cortex may be efficacious in reducing psychiatric symptoms; however, results are inconsistent regarding whether any parameter or treatment paradigm is superior. Other RCTs have targeted novel brain regions using newer TMS modalities. Combining TMS with psychotherapy may augment response in patients with PTSD, yet results are inconclusive. Little research has been done on TMS in combination with psychotherapy for GAD, indicating a need for further investigation. Future studies may assess TMS parameter optimization for enhancing effectiveness and improving therapeutic response duration. Identifying response biomarkers through functional magnetic resonance imaging and electroencephalography may offer a means to predict and monitor clinical response as precision methods to improve treatment response.

Indexed as

Anxiety DisordersStress Disorders, Post-TraumaticTranscranial Magnetic StimulationGeneralized Anxiety DisorderHumansGeneralized anxiety disorderNeuromodulationNon-invasive brain stimulationPosttraumatic stress disorderTranscranial magnetic stimulation

Identifiers

PMID39505816
PMCPMC13283335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.