Evidence map›Paper›PMID 39505805›Full record

ArticleMolecular neurobiology2025

Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia-Ischemia in Neonatal Rats.

Liam M Koehn, Kevin V Nguyen, Richard Tucker, Yow-Pin Lim, Xiaodi Chen, Barbara S Stonestreet

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liam M KoehnDepartment of Pediatrics, Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Women &101 Dudley Street, Providence, RI, 02905-2499, USA.
Kevin V NguyenDepartment of Pediatrics, Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Women &101 Dudley Street, Providence, RI, 02905-2499, USA.
Richard TuckerDepartment of Pediatrics, Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Women &101 Dudley Street, Providence, RI, 02905-2499, USA.
Yow-Pin LimProThera Biologics Inc, Providence, RI, USA.
Xiaodi ChenDepartment of Pediatrics, Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Women &101 Dudley Street, Providence, RI, 02905-2499, USA.
Barbara S StonestreetDepartment of Pediatrics, Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Women &101 Dudley Street, Providence, RI, 02905-2499, USA. bstonestreet@wihri.org.

Funding

Inter-alpha Inhibitors in Hypoxic-Ischemic Brain InjuryR44NS084575 · NINDS · PROTHERA BIOLOGICS, LLC · PI LIM, YOW-PIN · 2017 to 2023
$4.7M
Inter-alpha inhibitors: Novel neuroinflammatory modulator of neonatal brain injuryR21NS095130 · NINDS · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI STONESTREET, BARBARA S · 2016 to 2017
$441k
NIH HHS 1R21NS095130NINDS NIH HHS R44 NS084575
6 · The paper itself

Abstract

Inter-alpha inhibitor proteins (IAIPs) are neuroprotective and attenuate lipopolysaccharide (LPS)-mediated blood-brain barrier (BBB) disruption in neonatal rodents. We investigated some mechanism(s) fundamental to neuroprotection by IAIPs including changes in cerebral endothelial components and inflammation. Postnatal day-7 rats exposed to sham surgery and placebo or carotid ligation plus 8% FiO

Indexed as

CytokinesHypoxia-Ischemia, BrainMicrovesselsAlpha-GlobulinsAnimalsAnimals, NewbornBlood-Brain BarrierRatsRats, Sprague-DawleyAlpha-GlobulinsCytokinesinter-alpha-inhibitorBlood–brain barrierCytokinesHypoxia–ischemiaInflammationNeonate

Identifiers

PMID39505805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.