Evidence map›Paper›PMID 39505761›Full record

ArticleJournal of molecular neuroscience : MN2024

Antisecretory Factor 16 (AF16): A Promising Avenue for the Treatment of Traumatic Brain Injury-An In Vitro Model Approach.

Nicola Vahrmeijer, Jurgen Kriel, Bradley M Harrington, Anton Du Preez van Staden, Adriaan Johannes Vlok, Lize Engelbrecht, Andre Du Toit, Ben Loos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicola VahrmeijerDepartment of Physiological Sciences, Stellenbosch University, Merriman Avenue, Mike de Vries Building, Stellenbosch, 7600, South Africa.ORCID http://orcid.org/0000-0002-6856-6014
Jurgen KrielCentral Analytical Facilities, Stellenbosch University, Tygerberg Medical Campus, Clinical Building, 7Th Floor, Room 7063, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0001-7558-7916
Bradley M HarringtonDepartment of Neurosurgery, Tygerberg University Hospital, Tygerberg, Cape Town, South Africa.ORCID http://orcid.org/0009-0009-9242-7119
Anton Du Preez van StadenDivision Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-0596-8849
Adriaan Johannes VlokDepartment of Neurosurgery, Tygerberg University Hospital, Tygerberg, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-3202-2867
Lize EngelbrechtCentral Analytical Facilities, Stellenbosch University, Merriman Avenue, Mike de Vries Building, Stellenbosch, 7600, South Africa.ORCID http://orcid.org/0000-0002-4518-7011
Andre Du ToitDepartment of Physiological Sciences, Stellenbosch University, Merriman Avenue, Mike de Vries Building, Stellenbosch, 7600, South Africa.ORCID http://orcid.org/0000-0002-3936-6013
Ben LoosDepartment of Physiological Sciences, Stellenbosch University, Merriman Avenue, Mike de Vries Building, Stellenbosch, 7600, South Africa. bloos@sun.ac.za.ORCID http://orcid.org/0000-0002-5517-373X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is caused by an external mechanical force to the head, resulting in abnormal brain functioning and clinical manifestations. Antisecretory factor (AF16) is a potential therapeutic agent for TBI treatment due to its ability to inhibit fluid secretion and decrease inflammation, intracranial pressure, and interstitial fluid build-up, key hallmarks presented in TBI. Here, we investigated the effect of AF16 in an in vitro model of neuronal injury, as well as its impact on key components of the autophagy pathway and mitochondrial dynamics. N2A

Indexed as

AutophagyBrain Injuries, TraumaticAnimalsCell LineLysosomesMiceMitochondriaMitochondrial DynamicsNeuronsNeuroprotective AgentsNeuroprotective AgentsAntisecretory factor (AF16)AutophagyCorrelative light and electron microscopy (CLEM)Mitochondrial dynamicsTraumatic brain injury (TBI)

Identifiers

PMID39505761
PMCPMC11541381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.