Association between the Sp1-binding-site polymorphism in the collagen type I alpha 1 (COLIA1) gene and bone phenotypes: the Dubbo Osteoporosis Epidemiology Study.

Ngoc Huynh, Krisel De Dios, Thach S Tran, Jacqueline R Center, Tuan V Nguyen

Abstract read

In one paragraph

Article in Journal of bone and mineral metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Association between candidate genes and FRAX scores in postmenopausal women.Endocrine · 2026
Article
The Impact of SelectedInternational journal of molecular sciences · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ngoc HuynhSchool of Biomedical Engineering, University of Technology Sydney, City Campus (Broadway) Building 11, Level 10, PO BOX 123, Broadway, NSW, 2007, Australia.ORCID http://orcid.org/0009-0000-1321-628X

Krisel De DiosSchool of Biomedical Engineering, University of Technology Sydney, City Campus (Broadway) Building 11, Level 10, PO BOX 123, Broadway, NSW, 2007, Australia.

Thach S TranSchool of Biomedical Engineering, University of Technology Sydney, City Campus (Broadway) Building 11, Level 10, PO BOX 123, Broadway, NSW, 2007, Australia.

Jacqueline R CenterGarvan Institute of Medical Research, Sydney, Australia.

Tuan V NguyenSchool of Biomedical Engineering, University of Technology Sydney, City Campus (Broadway) Building 11, Level 10, PO BOX 123, Broadway, NSW, 2007, Australia. tuanvan.nguyen@uts.edu.au.

Funding

National Health and Medical Research Council (AU) APP1195305

6 · The paper itself

Abstract

introductionPolymorphisms within the collagen 1 alpha 1 gene (COLIA1) have been shown to be associated with bone mineral density (BMD). This study aimed to test the hypothesis that COLIA1 polymorphisms are associated with bone loss and fragility fractures. MATERIALS AND

methodsThe study involved 809 postmenopausal women aged 60 years and above in the Dubbo Osteoporosis Epidemiology Study who had COLIA1 genotypes and at least two BMD measurements over a 30-year period. BMD at the lumbar spine (LSBMD) and femoral neck (FNBMD) was measured biennially by dual-energy X-ray absorptiometry (GE-Lunar Prodigy). Fragility fracture has been ascertained by X-ray reports between 1990 and 2020. The G-> T polymorphism at the Sp1-binding site in the COLIA1 gene (rs1800012) was determined by the PCR-based method, and coded as GG, GT, and TT.

resultsWomen homozygous for the minor allele (TT) tended to have greater bone loss (-0.72%/year) than those with GT (-0.58%/year) or GG (-0.56%/year) though the difference did not achieve statistical significance (P = 0.84). Women of the TT genotype were associated with a two-fold greater risk of any fracture (adjusted hazard ratio: 2.21; 95%CI 1.42-3.46) and almost fourfold greater risk of hip fracture (3.78; 1.83-7.82) than those with either GG or GT genotype.

conclusionsPolymorphisms at the Sp1 site in the COLIA1 gene are associated with fracture risk, independent of bone loss.

Indexed as

Collagen Type IOsteoporosisOsteoporosis, PostmenopausalPolymorphism, Single NucleotideSp1 Transcription FactorAgedBone DensityCollagen Type I, alpha 1 ChainFemaleHumansMiddle AgedPhenotypeCOL1A1 protein, humanCollagen Type ICollagen Type I, alpha 1 ChainSP1 protein, humanSp1 Transcription FactorBone lossCOLIA1FractureGenetic variantsOsteoporosis

Identifiers

PMID39505754

DOI10.1007/s00774-024-01558-8

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.