Evidence map›Paper›PMID 39505745›Full record

ArticleAesthetic plastic surgery2025

Ultrasound-Guided "Cross Injection" Technique for Mouth Corner Lift with Botulinum Toxin Type A.

Kuangyun Tang, Yange Wu, Wen Wu, Kai Zheng, Sheng Wang, Xuepeng Chen

Abstract read
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In one paragraph

Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kuangyun TangKey Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Clinical Research Center for Oral Diseases of Zhejiang Province, School of Stomatology, Stomatology Hospital, Zhejiang University School of Medicine, No. 166, Qiutao North Road, Shangcheng District, Hangzhou, China.
Yange WuKey Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Clinical Research Center for Oral Diseases of Zhejiang Province, School of Stomatology, Stomatology Hospital, Zhejiang University School of Medicine, No. 166, Qiutao North Road, Shangcheng District, Hangzhou, China.
Wen WuKey Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Clinical Research Center for Oral Diseases of Zhejiang Province, School of Stomatology, Stomatology Hospital, Zhejiang University School of Medicine, No. 166, Qiutao North Road, Shangcheng District, Hangzhou, China.
Kai ZhengKey Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Clinical Research Center for Oral Diseases of Zhejiang Province, School of Stomatology, Stomatology Hospital, Zhejiang University School of Medicine, No. 166, Qiutao North Road, Shangcheng District, Hangzhou, China.
Sheng WangDivision of Orthodontics, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Xuepeng ChenKey Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Clinical Research Center for Oral Diseases of Zhejiang Province, School of Stomatology, Stomatology Hospital, Zhejiang University School of Medicine, No. 166, Qiutao North Road, Shangcheng District, Hangzhou, China. cxp1979@zju.edu.cn.ORCID 0000-0002-4948-577X

Funding

Fundamental Research Funds for the Central Universities 2020FZZX008-04Fundamental Research Funds for the Central Universities 2023QZJH60Funds of the Central Government Guiding Local Science and Technology Development 2023ZY1060Key Research and Development Program of Zhejiang Province 2023C03072R&D Program of the Stomatology Hospital of Zhejiang University School of Medicine RD2022DLYB03State Key Laboratory of Oral Diseases Open Fund SKLOD2023OF05Zhejiang traditional Chinese medicine science and technology plan project 2021ZB176
6 · The paper itself

Abstract

backgroundDrooping mouth corner may lead to a sad, tired or aging appearance, which could be corrected by injection of botulinum neurotoxin. In the article, we describe a novel "cross injection" technique for mouth corner lift with botulinum neurotoxin injection guided by ultrasound.

methodsPatients with drooping mouth corner were treated with botulinum neurotoxin injection using ultrasound-guided "cross injection" technique. The patient was told to contact the doctor immediately and return to the hospital as soon as the injection takes effect. The photographs of patients were taken during the follow-up appointment.

resultsAfter the injection, there were noticeable improvements on all patients. The mouth corners were elevated and desired effects were achieved.

conclusionsThe ultrasound-guided "cross injection" technique is precise and controllable, which can achieve stable aesthetic improvement of the drooped mouth corners, while significantly reducing the rate of injection-related complications. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Botulinum Toxins, Type ANeuromuscular AgentsUltrasonography, InterventionalAdultEstheticsFemaleFollow-Up StudiesHumansInjections, IntramuscularMaleMiddle AgedTreatment OutcomeBotulinum Toxins, Type ANeuromuscular AgentsBotulinum neurotoxinFacial rejuvenationPerioral regionUltrasonography

Identifiers

PMID39505745

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.