ArticleThe Journal of experimental medicine1986
Antibodies to basement membrane collagen and to laminin are present in sera from patients with poststreptococcal glomerulonephritis.
Article in The Journal of experimental medicine, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 86 citations in OpenAlex.
- C-reactive protein as a potential effector molecule in the pathogenesis of acute post-streptococcal glomerulonephritis: a narrative review.Pediatric nephrology (Berlin, Germany) · 2026Review
- Angiotensin II and post-streptococcal glomerulonephritis.Clinical and experimental nephrology · 2024Review
- Mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis.Pathogens and disease · 2024Review
- IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae ofFrontiers in cardiovascular medicine · 2022Article
- Eculizumab as a New Treatment for Severe Acute Post-infectious Glomerulonephritis: Two Case Reports.Frontiers in medicine · 2021Article
- Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis.Nature reviews. Nephrology · 2020Review
- Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae.Microbiology spectrum · 2019Review
- New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium.Journal of nephrology · 2014Review
- Approaching biomarkers of membranous nephropathy from a murine model to human disease.Journal of biomedicine & biotechnology · 2011Article
- Article
- Infection and glomerulonephritis.Seminars in immunopathology · 2007Review
- Pathogenesis of group A streptococcal infections.Clinical microbiology reviews · 2000Review
- Autoantibodies from mixed cryoglobulinaemia patients bind glomerular antigens.Clinical and experimental immunology · 1994Article
- Human anti-fibronectin antibodies in systemic lupus erythematosus: occurrence and antigenic specificity.Clinical and experimental immunology · 1994Article
- Isolation and characterization of a Streptococcus pyogenes protein that binds to basal laminae of human cardiac muscle.Infection and immunity · 1993Article
- Autoimmunity and glomerulonephritis.Postgraduate medical journal · 1992Review
- Rheumatic fever: changes in its incidence and presentation.BMJ (Clinical research ed.) · 1991Article
- The presence of laminin in the fetal human inner ear.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1991Article
- Anti-laminin antibodies in inner ear diseases: a potential marker for infectious and post-infectious processes.Archives of oto-rhino-laryngology · 1989Article
- Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Sera from patients with poststreptococcal glomerulonephritis (PSGN) known to have antibodies to proteoglycans were studied for the presence of antibodies against other basement membrane (BM) components. BM collagen (type IV) was isolated in the native state by extracting bovine anterior lens capsule (ALC) with 0.5 M acetic acid. The 7-S (collagenous) domain and the NC-1 (noncollagenous) domain of type IV collagen were obtained after bacterial collagenase digestion of ALC followed by gel filtration. Laminin was isolated from the mouse EHS tumor and fibronectin from human plasma. Immunologic studies, using an ELISA and electroimmunoblot, revealed the presence of antibodies that reacted with intact, native type IV collagen and the 7-S collagenous domain of this molecule. Reaction with the NC-1 (noncollagenous) domain was minimal, and not higher than that obtained with control sera. Laminin reaction strongly with the patients' sera, but fibronectin did not. Unlike sera from patients with Goodpasture syndrome, which contain antibodies primarily against the NC-1 (noncollagenous) domain of type IV collagen, sera from patients with acute PSGN contain antibodies against all the major macromolecular components of BM. This difference in immunologic reactivity may account for the observed differences in the pathologic picture at the glomerular level.
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