Evidence map›Paper›PMID 39505332›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Role of Abelson interactor 2 in progression and prognosis of gastric cancer and its regulatory mechanisms].

X Chen, H Lu, Z Wang, L Wang, Y Xia, Z Geng, X Zhang, X Song, Y Wang, J Li and 2 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

X ChenDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
H LuDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Z WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
L WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y XiaDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Z GengCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
X ZhangCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
X SongCentral Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Y WangDepartment of Laboratory Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
J LiDepartment of Laboratory Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
J HuDepartment of Laboratory Medicine, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
L ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the regulatory role of Abelson interactor 2 (ABI2) in progression and prognosis of gastric cancer.

methodsTIMER2.0, GEPIA, Kaplan-Meier Plotter and DAVID databases were used to analyze ABI2 expression in pancancer and its association with the prognosis of gastric cancer. Gastric cancer and adjacent tissues from 120 patients undergoing radical gastrectomy in our hospital between January, 2016 and October, 2018 were examined for ABI2 expression and its correlation with disease progression and prognosis. MGC-803 cell models of ABI2 knockdown and overexpression were established for observing the changes in cell proliferation, migration, and invasion, and the impact of ABI2 expression modulation on xenograft growth was evaluated in nude mice.

resultsDatabase analysis and examination of the clinical samples showed that ABI2 was highly expressed in gastric cancer tissues. Survival analysis suggested that gastric cancer patients with a high expression of ABI2 had a reduced postoperative 5-year survival rate (

conclusionABI2 is highly expressed in gastric cancer, which affects long-term prognosis of the patients, possible due to its regulatory effect on Wnt signaling to promote proliferation, migration and invasion of gastric cancer cells.

Indexed as

Cell ProliferationDisease ProgressionMice, NudeStomach NeoplasmsAdaptor Proteins, Signal TransducingAnimalsbeta CateninCell Line, TumorCell MovementFemaleGastrectomyHumansMaleMiceMiddle AgedNeoplasm InvasivenessAdaptor Proteins, Signal Transducingbeta CateninABI2gastric cancerinvasionmigrationprognosisproliferationWnt signaling pathway

Identifiers

PMID39505332
PMCPMC11744083

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