Trial reportArchives of physical medicine and rehabilitation2025
Causal Mediation Analysis of Factors Influencing Physical Activity and Community Access Among People With Mild-to-Moderate Parkinson Disease.
Trial report in Archives of physical medicine and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Causal Association Between Sleep Deprivation and Glioblastoma Risk: Insights from Multi-Omics Analysis.Journal of molecular neuroscience : MN · 2025Article
- The Role of AMPS in Parkinson's Disease Management: Scoping Review and Meta-Analysis.Bioengineering (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveTo examine how known causal factors (exercise self-efficacy, balance, walking capacity) affect outcomes (moderate-intensity physical activity, community access) in people with Parkinson disease (PD): through a direct pathway, indirectly through potential mediators (nonmotor impairments), or through combined direct and mediated paths.
designCausal mediation analyses using baseline and three-month data from pooled treatment groups in a randomized controlled trial.
settingData were collected at 2 university clinical research centers.
participantsOne hundred thirty-eight people with PD.
interventionsHome and community-based walking and strength exercise program. MAIN OUTCOME MEASURE(S): Exposures were exercise self-efficacy, walking capacity, and balance. Potential mediators included pain, fatigue, mood (anxiety, depression, affect, apathy), stigma, and cognition (executive function and cognitive flexibility). The outcomes were physical activity and community access behavior at follow-up 3 months later. Separate models were developed for each causal factor-mediator-outcome combination. To minimize bias, all models were adjusted for known confounders (comorbidities, freezing of gait, severity of motor impairment, and/or age) and baseline values of the outcomes.
resultsSelf-efficacy of walking duration had a causal relationship with moderate-intensity physical activity through direct and combined paths (P<.001). Walking capacity had a causal relationship with community access through direct (P=.03-.04) and combined (P=.02-.03) paths. Balance did not affect community access (P>.05). There were no significant mediation effects through indirect pathways for either outcome.
conclusionsThe effect of known causal factors on physical activity and community access was not mediated by nonmotor impairments. Walking self-efficacy and walking capacity remain the primary intervention targets for improving physical activity and community access, respectively, in people with PD.
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