Evidence map›Paper›PMID 39505231›Full record

ArticleMolecular and cellular endocrinology2025

PRDM16 in thermogenic adipocytes mediates an inter-organ protective signaling against alcohol-associated liver disease.

Shanshan Liu, Kezhou Zhu, Yunying Huang, Weilai Ye, Jun Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shanshan LiuLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Kezhou ZhuLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Yunying HuangLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Weilai YeLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA.
Jun WuLife Sciences Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. Electronic address: wujunz@umich.edu.

Funding

The role of immune-adipocyte cholinergic signaling during metabolic adaptation and dysfunctionR01DK107583 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WU, JUN · 2016 to 2024
$3.4M
A novel cholinergic circuitry in alcoholic liver disease (NIAAA)R01AA028761 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WU, JUN · 2021 to 2025
$2.1M
NIAAA NIH HHS R01 AA028761NIDDK NIH HHS R01 DK107583
6 · The paper itself

Abstract

Alcohol-associated liver disease (ALD) is one of the major chronic liver diseases and despite the dire clinical needs and extensive research efforts, no effective therapies are available for late-stages of ALD except for liver transplantation. Adipose tissue dysfunction has been implicated in the progression of ALD. Furthermore, it has been previously suggested that thermogenic fat can be activated after alcohol consumption. In this study, increased thermogenic gene expression was detected in both classical brown adipose tissue and beige adipocytes in mice that were given alcohol challenges even when housed at thermoneutrality. In particular, higher expression level of Prdm16, the key transcriptional co-component for beige fat function, was observed in the subcutaneous fat of mice after alcohol challenges. The objective of the present study is to explore the functional significance of adipocyte PRDM16 in the context of ALD. Even though Prdm16 adipocyte-specific-deleted mice (Prdm16-adKO) did not show liver defects at the basal level, following two different alcohol challenge regimens, exacerbated ALD phenotypes were observed in Prdm16-adKO mice compared to that of the control Prdm16

Indexed as

DNA-Binding ProteinsLiver Diseases, AlcoholicMice, KnockoutSignal TransductionThermogenesisTranscription FactorsAdipocytesAdipose Tissue, BrownAnimalsEthanolLiverMaleMiceMice, Inbred C57BLDNA-Binding ProteinsEthanolPrdm16 protein, mouseTranscription FactorsAlcohol-associated liver diseaseBeige adipocytesPRDM16Thermogenic fat

Identifiers

PMID39505231
PMCPMC12044534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.