Evidence map›Paper›PMID 39504934›Full record

ReviewTrends in microbiology2024

Tradeoffs and constraints on the evolution of tailocins.

Talia Backman, Hernán A Burbano, Talia L Karasov

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Genome Evolution in Plant Pathogenic Bacteria.Genome biology and evolution · 2026
    Review
  3. Persistent trade-offs balance competition and colonization across centuries.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Beyond kin killing:ISME communications · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Microbial Nanoparticles in Biological Plant Protection.International journal of molecular sciences · 2025
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Talia BackmanSchool of Biological Sciences, University of Utah 257S 1400E, Salt Lake City, UT 84112, USA. Electronic address: talia.backman@utah.edu.
Hernán A BurbanoCentre for Life's Origins and Evolution, Department of Genetics, Evolution, and Environment, University College London, London, UK. Electronic address: h.burbano@ucl.ac.uk.
Talia L KarasovSchool of Biological Sciences, University of Utah 257S 1400E, Salt Lake City, UT 84112, USA. Electronic address: talia.karasov@utah.edu.

Funding

Training Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0M
University of Utah Genetics Training ProgramT32GM141848 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GOLIC, KENT G, GRUNWALD, DAVID J. · 2021 to 2025
$2.9M
Identifying limitations on microbial host jumpsR35GM150722 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Talia Karasov · 2023 to 2026
$1.5M
NIAID NIH HHS T32 AI055434NIGMS NIH HHS R35 GM150722NIGMS NIH HHS T32 GM141848
6 · The paper itself

Abstract

Phage tail-like bacteriocins (tailocins) are protein complexes produced by bacteria with the potential to kill their neighbors. Widespread throughout Gram-negative bacteria, tailocins exhibit extreme specificity in their targets, largely killing closely related strains. Despite their presence in diverse bacteria, the impact of these competitive weapons on the surrounding microbiota is largely unknown. Recent studies revealed the rapid evolution and genetic diversity of tailocins in microbial communities and suggest that there are constraints on the evolution of specificity and resistance. Given the precision of their targeted killing and the ease of engineering new specificities, understanding the evolution and ecological impact of tailocins may enable the design of promising candidates for novel targeted antibiotics.

Indexed as

Anti-Bacterial AgentsBacteriocinsBacteriaBacteriophagesEvolution, MolecularGenetic VariationGram-Negative BacteriaMicrobiotaAnti-Bacterial AgentsBacteriocinsbacterial competitionmicrobiome evolutiontailocintradeoffs

Identifiers

PMID39504934
PMCPMC12090994

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.