Evidence map›Paper›PMID 39504608›Full record

ReviewDNA repair2024

Genome organization and stability in mammalian pre-implantation development.

Shuangyi Xu, Dieter Egli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in DNA repair, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shuangyi XuDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA.
Dieter EgliDivision of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA; Department of Obstetrics and Gynecology, Columbia University, New York, NY 10032, USA. Electronic address: de2220@cumc.columbia.edu.

Funding

Causes and Consequences of DNA Replication Stress in the Mammalian Preimplantation EmbryoR01HD113698 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dieter Meinrad Egli · 2024 to 2026
$2.1M
DNA repair pathway choice mediates somatic cell reprogrammingR01GM132604 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EGLI, DIETER MEINRAD · 2020 to 2023
$1.9M
NICHD NIH HHS R01 HD113698NIGMS NIH HHS R01 GM132604
6 · The paper itself

Abstract

A largely stable genome is required for normal development, even as genetic change is an integral aspect of reproduction, genetic adaptation and evolution. Recent studies highlight a critical window of mammalian development with intrinsic DNA replication stress and genome instability in the first cell divisions after fertilization. Patterns of DNA replication and genome stability are established very early in mammals, alongside patterns of nuclear organization, and before the emergence of gene expression patterns, and prior to cell specification and germline formation. The study of DNA replication and genome stability in the mammalian embryo provides a unique cellular system due to the resetting of the epigenome to a totipotent state, and the de novo establishment of the patterns of nuclear organization, gene expression, DNA methylation, histone modifications and DNA replication. Studies on DNA replication and genome stability in the early mammalian embryo is relevant for understanding both normal and disease-causing genetic variation, and to uncover basic principles of genome regulation.

Indexed as

DNA ReplicationEmbryonic DevelopmentGenomic InstabilityAnimalsDNA MethylationEmbryo, MammalianGene Expression Regulation, DevelopmentalGenomeHumansMammalsA/B compartmentChromosomal breakageDNA damageLower vertebratesMammalsMosaicismNuclear laminaPreimplantation developmentReplication stress

Identifiers

PMID39504608
PMCPMC11613952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.