Evidence map›Paper›PMID 39504606›Full record

ArticlePsychoneuroendocrinology2025

Ventral subiculum control of avoidance behavior and hypothalamic-pituitary-adrenal axis reactivity via the bed nucleus of the stria terminalis in male and female mice - ISPNE 2024 Dirk Helhammer Award.

Jena S Marsh, Cara Teixeira, Swapnil Gavade, Colin Johnston, Salisha Baranwal, Christen N Snyder, Chih-Lin Chang, Shany Yang, Joanna L Spencer-Segal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Wake Up and Smell-the Cortisol?The Journal of clinical endocrinology and metabolism · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jena S MarshMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Cara TeixeiraMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Swapnil GavadeMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Colin JohnstonMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Salisha BaranwalMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Christen N SnyderMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Chih-Lin ChangMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Shany YangMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Joanna L Spencer-SegalMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sjoanna@med.umich.edu.

Funding

Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Neural and Molecular Mechanisms of Emotional Dysfunction after SepsisK08MH116267 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCER-SEGAL, JOANNA LOUISE · 2018 to 2022
$845k
A Common Neuronal Pathway for the Behavioral and Neuroendocrine Response to Potential ThreatF31MH126511 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GEWARGES, EUPHEMIA (JENA) SABAH · 2021 to 2023
$118k
NIMH NIH HHS F31 MH126511NIMH NIH HHS K08 MH116267NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Avoidance or anxiety-like behavior is accompanied by corresponding changes in hypothalamic-pituitary-adrenal (HPA) axis activation. The underlying neural circuitry for this coordinated behavioral and neuroendocrine control is not well established. Prior studies pointed to a neural projection from the ventral subiculum (vSub) to the bed nucleus of the stria terminalis (BNST) that can inhibit the HPA axis response to stress. Here, we used chemogenetics to investigate the role of vSub neurons and their projection to the anterior BNST (aBNST) in avoidance behavior and the accompanying corticosterone response in male and female mice. Surprisingly, we found that chemogenetic activation of ventral subiculum neurons increased the HPA axis response to an open field test in male and female mice, which was also seen with selective activation of vSub neurons projecting to the anterior BNST (vSub-aBNST neurons). On the other hand, VSub neuron and vSub-aBNST neuron activation had different effects on avoidance behavior, suggesting that the behavioral role of the VSub is variable and is dissociable from its neuroendocrine effects. In conclusion, our results reveal a surprising and novel role for the ventral subiculum in HPA axis activation via the anterior BNST. We also show that, like the ventral hippocampus, ventral subiculum neurons can increase or decrease avoidance behavior depending on their downstream projection.

Indexed as

Avoidance LearningCorticosteroneHippocampusHypothalamo-Hypophyseal SystemNeuronsPituitary-Adrenal SystemSeptal NucleiAnimalsAnxietyBehavior, AnimalFemaleMaleMiceMice, Inbred C57BLNeural PathwaysStress, PsychologicalCorticosteroneAnxietyAvoidanceGlucocorticoidHPA axisStressSubiculum

Identifiers

PMID39504606
PMCPMC12034369

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.