Evidence map›Paper›PMID 39504504›Full record

ArticleNeurology2024

Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk.

Sandro Marini, Tamara N Kimball, Ernst Mayerhofer, Reinier W P Tack, Jasper R Senff, Savvina Prapiadou, Cyprien A Rivier, Jonathan Duskin, Christina Kourkoulis, Guido J Falcone and 6 more

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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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6 citing papers in PubMed.

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5 · Who and what money

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16 authors.

Sandro MariniFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0003-1702-8168
Tamara N KimballFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.
Ernst MayerhoferFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.
Reinier W P TackFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0003-3204-0309
Jasper R SenffFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0009-0002-6540-480X
Savvina PrapiadouFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-7415-2566
Cyprien A RivierFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-1148-1829
Jonathan DuskinFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.
Christina KourkoulisFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-6330-9169
Guido J FalconeFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-6407-0302
Nirupama YechoorFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-6479-9155
Rudolph E TanziFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-7032-1454
Jonathan RosandFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-1014-9138
Sanjula SinghFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0001-9304-8107
Livia ParodiFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.
Christopher D AndersonFrom the Henry and Allison McCance Center for Brain Health (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), Department of Neurology (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., R.E.T., J.R., S.S., L.P., C.D.A.), and Division of Neuropsychiatry (C.D.A.), Massachusetts General Hospital, Boston; Broad Institute of MIT and Harvard (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Cambridge; Center for Genomic Medicine (S.M., T.N.K., E.M., R.W.P.T., J.R.S., S.P., J.D., C.K., N.Y., J.R., S.S., L.P., C.D.A.), Massachusetts General Hospital; Department of Neurology (S.M., T.N.K., J.D., L.P., C.D.A.), Brigham and Women's Hospital, Boston, MA; Department of Neurology (R.W.P.T., J.R.S., S.S.), Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands; Yale Center for Brain and Mind Health (C.A.R., G.J.F.), and Department of Neurology, Yale School of Medicine, New Haven, CT.ORCID 0000-0002-0053-2002

Funding

Training Program in Recovery and Restoration of CNS health and functionT32NS100663 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LEIGH R HOCHBERG, JONATHAN ROSAND · 2017 to 2026
$2.5M
American Heart Association-American Stroke Association 812095NINDS NIH HHS T32 NS100663
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of age-related brain disease, including stroke, late-life depression (LLD), and dementia. A higher BCS at baseline is associated with a lower risk of these outcomes. We aimed to investigate whether the associations between BCS and stroke, LLD, and dementia risks are independent of genetic predisposition for these conditions and quantify the effect of healthy lifestyle across genetic risk distributions for these outcomes.

methodsUsing the UK Biobank (UKB) prospective cohort study, we computed baseline BCSs and polygenic scores to estimate genetic predisposition for stroke and LLD and

resultsWe included 368,340 UKB participants (median age 58 years (interquartile range 51-63 years), 46.3% male). Independent of genetic risk, a 5-point increase in BCS corresponded to lowered hazards of stroke (hazard ratio [HR] 0.70, 95% CI 0.68-0.73), LLD (HR 0.65, 95% CI 0.63-0.67), and dementia (HR 0.82, 95% CI 0.78-0.85). Incidences of all 3 outcomes were higher among participants with high genetic risk of these outcomes. However, these increased risks were offset for individuals with a higher BCS (incidence rates per 1,000 person-years were 2.76 vs 1.19 for stroke, 7.34 vs 4.46 for LLD, and 3.64 vs 2.05 for dementia, when comparing low and high BCS). DISCUSSION: Across different genetic predispositions for stroke, LLD, and dementia, healthier lifestyle behaviors are protective for brain health, demonstrating the nondeterminism of genetic risk. Furthermore, differences in BCS behave as aggregate risk estimators of all 3 outcomes. Further work is needed to prospectively investigate the utility and performance of the BCS as a targeted intervention in populations at elevated genetic risk of age-related brain disease.

Indexed as

DementiaGenetic Predisposition to DiseaseStrokeAgedApolipoproteins ECohort StudiesDepressionFemaleHealth BehaviorHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsUnited KingdomApolipoproteins E

Identifiers

PMID39504504
PMCPMC12307029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.