ArticleMedical physics2025
Oxygen consumption measurements at ultra-high dose rate over a wide LET range.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- FLASH radiotherapy: physico-chemical considerations on ionisation tracks, radical reactions, and the role of oxygen.Radiation oncology (London, England) · 2026Review
- Radiation-Induced Modifications in Bovine Serum Albumin in Saline Solutions Under E-Beam Irradiation.International journal of molecular sciences · 2026Article
- Kinetic model of radiochemical oxygen depletion (ROD) in FLASH radiotherapy.Medical physics · 2026Article
- Oxygen Depletion in FLASH Particle Therapy: Effects of Linear Energy Transfer and Ion Track Structure.Antioxidants (Basel, Switzerland) · 2026Article
- Factors Influencing the Biological Effects of FLASH Irradiation.Antioxidants (Basel, Switzerland) · 2025Review
- First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Oxygen consumption measurements at ultra-high dose rate over a wide LET range.Medical physics · 2025Article
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15 authors.
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Abstract
backgroundThe role of radiolytic oxygen consumption for the in-vitro "Ultra-High Dose Rate" (UHDR) sparing and in-vivo FLASH effect is subject to active debate, but data on key dependencies such as the radiation quality are lacking. PURPOSE: The influence of "dose-averaged Linear Energy Transfer" (LETd) and dose rate on radiolytic oxygen consumption was investigated by monitoring the oxygen concentration during irradiation with electrons, protons, helium, carbon, and oxygen ions at UHDR and "Standard Dose Rates" (SDR).
methodsSealed "Bovine Serum Albumin" (BSA) 5% samples were exposed to 15 Gy of electrons and protons, and for the first time helium, carbon, and oxygen ions with LETd values of 1, 5.4, 14.4, 65, and 100.3 keV/µm, respectively, delivered at mean dose rates of either 0.3-0.4 Gy/s for SDR or approximately 100 Gy/s for UHDR. The Oxylite (Oxford Optronics) system allowed measurements of the oxygen concentration before and after irradiation to calculate the oxygen consumption rate.
resultsThe oxygen consumption rate was found to decrease with increasing LETd from 0.351 mmHg/Gy for low LET electrons to 0.1796 mmHg/Gy for high LET oxygen ions at SDR and for UHDR from 0.317 to 0.1556 mmHg/Gy, respectively. A higher consumption rate for SDR irradiation compared to the corresponding UHDR irradiation persisted for all particle types.
conclusionThe measured consumption rates demonstrate a distinct LETd dependence. The obtained dataset, encompassing a wide range of LETd values, could serve as a benchmark for Monte Carlo simulations, which may aid in enhancing our comprehension of oxygen-related mechanisms after irradiations. Ultimately, they could help assess the viability of different hypotheses regarding UHDR sparing mechanisms and the FLASH effect. The found LETd dependence underscores the potential of heavy ion therapy, wherein elevated consumption rates in adjacent normal tissue offer protective benefits, while leaving tumor regions with generally higher "Linear Energy Transfer" (LET) vulnerable.
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