Evidence map›Paper›PMID 39504353›Full record

ArticleScience translational medicine2024

The

Rebecca L Wallings, Karen McFarland, Hannah A Staley, Noelle Neighbarger, Susen Schaake, Norbert Brüggemann, Simone Zittel, Tatiana Usnich, Christine Klein, Esther M Sammler and 1 more

Abstract read
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Parkinson's-Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  5. Article
  6. Review
  7. Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers ofmedRxiv : the preprint server for health sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rebecca L WallingsDepartment of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL, USA.ORCID 0000-0003-0947-4459
Karen McFarlandCenter for Translational Research in Neurodegenerative Disease, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL, USA.ORCID 0000-0002-9952-8678
Hannah A StaleyDepartment of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL, USA.ORCID 0009-0001-8284-6178
Noelle NeighbargerDepartment of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL, USA.ORCID 0009-0007-6649-0988
Susen SchaakeInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID 0009-0006-6021-3069
Norbert BrüggemannInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Simone ZittelDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tatiana UsnichInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID 0000-0001-7335-8888
Christine KleinAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.ORCID 0000-0003-2102-3431
Esther M SammlerAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.ORCID 0000-0003-3218-7116
Malú Gámez TanseyDepartment of Neuroscience, University of Florida, College of Medicine, McKnight Brain Institute, Gainesville, FL, USA.

Funding

Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationRF1NS128800 · NINDS · UNIVERSITY OF FLORIDA · PI FINKBEINER, STEVEN M, TANSEY, MARIA DE LOURDES GAMEZ · 2022 to 2022
$2.4M
Role of Gut Inflammation and Immunity on Proteostasis, Noradrenergic Degeneration and AD riskRF1AG057247 · NIA · UNIVERSITY OF FLORIDA · PI NEISH, ANDREW S, TANSEY, MARIA DE LOURDES GAMEZ · 2017 to 2017
$1.6M
NIA NIH HHS RF1 AG057247NINDS NIH HHS RF1 NS128800
6 · The paper itself

Abstract

Age is the greatest risk factor for many neurodegenerative diseases, yet immune system aging, a contributor to neurodegeneration, is understudied. Genetic variation in the

Indexed as

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2MutationMyeloid CellsAge FactorsAgingAnimalsAntigen PresentationFemaleHumansLysosomesMacrophages, PeritonealMaleMiceMice, Inbred C57BLSex CharacteristicsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lrrk2 protein, mouse

Identifiers

PMID39504353
PMCPMC12718673

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.