ArticleCell reports2024
SARS-CoV-2 infection elucidates features of pregnancy-specific immunity.
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Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes.bioRxiv : the preprint server for biology · 2025Article
- Global, regional, and national trends and burden of hypertensive disorders in pregnancy among women of childbearing age from 1990 to 2021.Frontiers in global women's health · 2025Article
- Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women.Frontiers in immunology · 2025Article
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Authors and funding
34 authors.
Dong Sun OhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Eunha KimDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; BK21 Graduate Program, Department of Biomedical Sciences and Department of Neuroscience, Korea University College of Medicine, Seoul 02841, Republic of Korea.
Rachelly NormandCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
Guangqing LuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Lydia L ShookDepartment of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Amanda LyallDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Olyvia JassetVincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Stepan DemidkinVincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Emily GilbertVincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Joon KimVincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Babatunde AkinwunmiVincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Jessica TantivitCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Alice TirardCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Benjamin Y ArnoldCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Kamil SlowikowskiCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
MGH COVID-19 Collection & Processing Team
Marcia B GoldbergBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Michael R FilbinBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Nir HacohenKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Long H NguyenDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Xu G YuInfectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jonathan Z LiDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Lael YonkerMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Alessio FasanoDivision of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, MA 02114, USA.
Roy H PerlisDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kathryn J GrayDepartment of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195, USA.
Gloria B ChoiThe Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David A DrewDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Pritha SenCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Transplant, Oncology, and Immunocompromised Host Group, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Alexandra-Chloé VillaniCenter for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: avillani@mgh.harvard.edu.
Andrea G EdlowDepartment of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: aedlow@mgh.harvard.edu.
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jun_huh@hms.harvard.edu.
Funding
Cellular models of fetal neurodevelopment in maternal SARS-CoV-2 infectionRF1MH132336 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, ANDREA GOLDBERG, PERLIS, ROY H. · 2022 to 2022
$2.6MDeciphering the Achilles Heel of Cancer ImmunotherapyDP2CA247831 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VILLANI, ALEXANDRA-CHLOE · 2019 to 2019
$2.5MSex Differences in Fetal Brain-Placental Immune Programming in Maternal ObesityR01HD100022 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, ANDREA GOLDBERG · 2019 to 2021
$2.0MTransdisciplinary Harvard WRHR Career Development for Gynecologists and ObstetriciansK12HD103096 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NOUR, NAWAL M. · 2020 to 2024
$1.5MSignatures of dysfunctional mitochondrial fatty acid oxidation that predispose to early-onset preeclampsiaK08HL146963 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GRAY, KATHRYN JOHNSON · 2019 to 2023
$940kHigh-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantationK08HL157725 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SEN, PRITHA · 2021 to 2025
$929kNCI NIH HHS DP2 CA247831NHLBI NIH HHS K08 HL146963NHLBI NIH HHS K08 HL157725NICHD NIH HHS K12 HD103096NICHD NIH HHS R01 HD100022NIMH NIH HHS RF1 MH132336
Abstract
Pregnancy is a risk factor for increased severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory infections, but the mechanisms underlying this risk are poorly understood. To gain insight into the role of pregnancy in modulating immune responses at baseline and upon SARS-CoV-2 infection, we collected peripheral blood mononuclear cells and plasma from 226 women, including 152 pregnant individuals and 74 non-pregnant women. We find that SARS-CoV-2 infection is associated with altered T cell responses in pregnant women, including a clonal expansion of CD4-expressing CD8
Indexed as
CD8-Positive T-LymphocytesCOVID-19CytokinesPregnancy Complications, InfectiousSARS-CoV-2AdultCD4-Positive T-LymphocytesFemaleHumansLeukocytes, MononuclearPregnancyCytokinesCOVID-19CP: Immunologycytokinesimmune cellsimmune responsesmaternal immune activationpregnancySARS-CoV-2single-cell RNA-seqT cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.