Evidence map›Paper›PMID 39503955›Full record

ArticleJournal of microbiology (Seoul, Korea)2024

Inhibition of Virulence Associated Traits by β-Sitosterol Isolated from Hibiscus rosa-sinensis Flowers Against Candida albicans: Mechanistic Insight and Molecular Docking Studies.

Pallvi Mohana, Atamjit Singh, Farhana Rashid, Sharabjit Singh, Kirandeep Kaur, Rupali Rana, Preet Mohinder Singh Bedi, Neena Bedi, Rajinder Kaur, Saroj Arora

Abstract read
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In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Food science & nutrition · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pallvi MohanaDepartment of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India. psmohana468@gmail.com.ORCID http://orcid.org/0009-0005-4460-1785
Atamjit SinghDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Farhana RashidDepartment of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Sharabjit SinghDepartment of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Kirandeep KaurDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Rupali RanaDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Preet Mohinder Singh BediDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Neena BediDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Rajinder KaurDepartment of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.
Saroj AroraDepartment of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Funding

University Grants Commission UGC-Ref.No:668
6 · The paper itself

Abstract

The emerging drug resistance and lack of safer and more potent antifungal agents make Candida infections another hot topic in the healthcare system. At the same time, the potential of plant products in developing novel antifungal drugs is also in the limelight. Considering these facts, we have investigated the different extracts of the flowers of Hibiscus rosa-sinensis of the Malvaceae family for their antifungal efficacy against five different pathogenic Candida strains. Among the various extracts, the chloroform extract showed the maximum zone of inhibition (26.6 ± 0.5 mm) against the Candida albicans strain. Furthermore, the chloroform fraction was isolated, and a sterol compound was identified as β-sitosterol. Mechanistic studies were conducted to understand the mechanism of action, and the results showed that β-sitosterol has significant antifungal activity and is capable of interrupting biofilm formation and acts by inhibiting ergosterol biosynthesis in Candida albicans cells. Microscopic and molecular docking studies confirmed these findings. Overall, the study validates the antifungal efficacy of Candida albicans due to the presence of β-sitosterol which can act as an effective constituent for antifungal drug development individually or in combination.

Indexed as

Antifungal AgentsBiofilmsCandida albicansErgosterolFlowersHibiscusMicrobial Sensitivity TestsMolecular Docking SimulationPlant ExtractsSitosterolsVirulenceAntifungal AgentsErgosterolgamma-sitosterolPlant ExtractsSitosterolsAntibiofilmAntifungalCandida albicansHibiscus rosa-sinensisMolecular docking studiesβ-Sitosterol

Identifiers

PMID39503955

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.