Evidence map›Paper›PMID 39503943›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

Symptom prevalence in patients with advanced heart failure and its association with quality of life and activities of daily living.

Moritz Blum, Karen McKendrick, Laura P Gelfman, Nathan E Goldstein

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01459744 (An Intervention to Improve ICD Deactivation Conversations), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01459744 nacompletednot on this map

An Intervention to Improve ICD Deactivation Conversations (WISDOM - Working to Improve discuSsions About DefibrillatOr Management)

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2011 to 2016Enrolled562ConditionsCommunication, Heart FailureArmsCommunication training for cardiologists., Control arm
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Moritz BlumBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. moritz.blum@charite.de.ORCID http://orcid.org/0000-0003-3221-0048
Karen McKendrickBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura P GelfmanBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nathan E GoldsteinBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MELISSA Diane ALDRIDGE, R. Sean Morrison · 2010 to 2026
$21.9M
An Intervention to Improve ICD Deactivation ConversationsR01HL102084 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOLDSTEIN, NATHAN E · 2011 to 2015
$3.1M
Goals of Care Discussions in Older Adults with Heart Failure and Their CaregiversK23AG049930 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELFMAN, LAURA PILAR · 2016 to 2022
$816k
Cambia Health Foundation Sojourns Scholars Leadership AwardClaude D. Pepper Older American Independence Center at the Icahn School of Medicine at Mount Sinai 5P30AG028741NHLBI NIH HHS R01 HL102084NHLBI NIH HHS R01HL102084NIA NIH HHS K23 AG049930NIA NIH HHS K23AG049930NIA NIH HHS P30 AG028741
6 · The paper itself

Abstract

backgroundQuality of life (QOL) and functional status are two key outcomes for patients with advanced heart failure (HF). We examined the association of eleven symptoms with QOL and functional status impairment in patients with advanced HF. METHODS AND

resultsThis was a retrospective analysis of baseline data from a multi-center, cluster-randomized controlled trial (NCT01459744) which enrolled patients with an implanted cardioverter-defibrillator and advanced HF at high-risk for mortality. Study instruments included the Condensed Memorial Symptom Assessment Scale, the Kansas City Cardiomyopathy Questionnaire QOL subscale, and the number of activities of daily living (ADL) patients had difficulties with. The study included 413 subjects. In generalized linear models which were adjusted for baseline characteristics, the total number of symptoms was significantly associated with worse QOL, as was the presence of each individual symptom, except constipation. Lack of energy demonstrated the strongest negative association with QOL. Similarly, the total number of symptoms was associated with a higher number of ADL difficulties (i.e., worse functional status). The presence of pain, lack of energy and drowsiness was individually associated with more ADL difficulties.

conclusionAmong patients with advanced HF, a higher number of symptoms and specific individual symptoms were associated with worse QOL and functional status.

Indexed as

Activities of Daily LivingHeart FailureQuality of LifeAgedFemaleHumansMaleMiddle AgedPrevalenceRetrospective StudiesSurveys and QuestionnairesActivities of daily livingAdvanced heart failureQuality of lifeSymptoms

Identifiers

PMID39503943
PMCPMC12135210

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.